Evidence map›Paper›PMID 28303627›Full record

ArticleBJU international2017

cAMP-dependent regulation of RhoA/Rho-kinase attenuates detrusor overactivity in a novel mouse experimental model.

William Akakpo, Biljana Musicki, Arthur L Burnett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJU international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

William AkakpoThe James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1683-0079
Biljana MusickiThe James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Arthur L BurnettThe James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

NOS Regulation in the PenisR01DK067223 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BURNETT, ARTHUR LOUIS · 2005 to 2015
$3.5M
NIDDK NIH HHS R01 DK067223
6 · The paper itself

Abstract

objectiveTo investigate detrusor function and cAMP activation as a possible target for detrusor overactivity in an experimental model lacking a key denitrosylation enzyme, S-nitrosoglutathione reductase (GSNOR). MATERIALS AND

methodsGSNOR-deficient (GSNOR

resultsGSNOR

conclusionImpaired denitrosylation is associated with detrusor overactivity, which is linked with upregulated RhoA/Rho-kinase signalling. Colforsin reverses physiological and molecular abnormalities. This study describes a novel model of detrusor overactivity and suggests a possible basis for its treatment.

Indexed as

AnimalsDisease Models, AnimalEndothelium, VascularMaleMiceMice, Inbred C57BLMuscle ContractionNitric OxideOxidative StressPenisrhoA GTP-Binding Proteinrho-Associated Kinasesrho GTP-Binding ProteinsSignal TransductionUp-RegulationUrinary Bladder, OveractiveNitric OxiderhoA GTP-Binding ProteinRhoA protein, mouserho-Associated Kinasesrho GTP-Binding Proteinsanimal modelcystometrynitric oxideoveractive bladdertransnitrosylation

Identifiers

PMID28303627
PMCPMC5479688
OpenAlexW2597049067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.