ArticleMagnetic resonance in medicine2018
Joint system relaxometry (JSR) and Crámer-Rao lower bound optimization of sequence parameters: A framework for enhanced precision of DESPOT T
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- RF phase modulation improves quantitative transient state sequences under constrained conditions.Magma (New York, N.Y.) · 2026Article
- High-resolution quantitative TImaging neuroscience (Cambridge, Mass.) · 2025Article
- Cramér-Rao Bound Optimized Subspace Reconstruction in Quantitative MRI.IEEE transactions on bio-medical engineering · 2025Article
- In vivo T2 measurements of the fetal brain using single-shot fast spin echo sequences.Magnetic resonance in medicine · 2024Article
- Widespread, depth-dependent cortical microstructure alterations in pediatric focal epilepsy.Epilepsia · 2024Article
- Article
- Optimization of spin-lock times for TScientific reports · 2022Article
- Cramér-Rao bound-informed training of neural networks for quantitative MRI.Magnetic resonance in medicine · 2022Article
- Optimization of spin-lock times in TMagnetic resonance in medicine · 2022Article
- An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging.Magnetic resonance in medicine · 2022Article
- Using quantitative MRI to study brain responses to immune challenge with interferon-α.Brain, behavior, & immunity - health · 2021Article
- Efficiency analysis for quantitative MRI of T1 and T2 relaxometry methods.Physics in medicine and biology · 2021Article
- Free-breathing abdominal TNMR in biomedicine · 2021Article
- Multidimensional correlation spectroscopic imaging of exponential decays: From theoretical principles to in vivo human applications.NMR in biomedicine · 2020Article
- Controlled saturation magnetization transfer for reproducible multivendor variable flip angle TMagnetic resonance in medicine · 2020Article
- Impact of (k,t) sampling on DCE MRI tracer kinetic parameter estimation in digital reference objects.Magnetic resonance in medicine · 2020Article
- Magnetic resonance fingerprinting review part 2: Technique and directions.Journal of magnetic resonance imaging : JMRI · 2020Review
- High-resolution in vivo MR-STAT using a matrix-free and parallelized reconstruction algorithm.NMR in biomedicine · 2020Article
- Flexible and efficient optimization of quantitative sequences using automatic differentiation of Bloch simulations.Magnetic resonance in medicine · 2019Article
- Optimized quantification of spin relaxation times in the hybrid state.Magnetic resonance in medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to increase the precision of single-compartment DESPOT relaxometry by two means: (i) a joint system relaxometry (JSR) approach that estimates parameters in a single step using all available data; and (ii) optimizing acquisition parameters by deploying a robust design tool based on the Crámer-Rao lower bound (CRLB).
methodsFollowing the development of the analysis and design capabilities, phantom and four in vivo subject experiments were performed to compare directly the precision achieved with DESPOT and JSR estimation using published protocols and protocols designed using a proposed CRLB framework.
resultsExperimental data demonstrate JSR's ability to decrease relaxometry estimation variance. Phantom results show 72 to 77% improvement using the same data as conventional DESPOT. This is further improved to 81 to 87% using optimal parameters. Both experiments show systematic bias depending on the acquisition parameters used, which are shown to be highly reproducible and to vary with different magnetization transfer conditions.
conclusionsCompared with DESPOT, JSR produces reproducible relaxation maps with improved precision. Further improvement was achieved using CRLB as a protocol design tool. With this combined approach, it is possible to achieve submillimeter maps of ρ,T1,T2, and B0 in an 11-min examination, making the approach appealing for potential clinical use. Magn Reson Med 79:234-245, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.