Evidence map›Paper›PMID 28303582›Full record

ArticleMedical physics2017

Generation and analysis of clinically relevant breast imaging x-ray spectra.

Andrew M Hernandez, J Anthony Seibert, Anita Nosratieh, John M Boone

Abstract read
In one paragraph

Article in Medical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew M HernandezDepartment of Radiology, Biomedical Engineering Graduate Group, University of California Davis, Sacramento, CA, 95817, USA.
J Anthony SeibertDepartment of Radiology and Biomedical Engineering, Biomedical Engineering Graduate Group, University of California Davis, Sacramento, CA, 95817, USA.
Anita NosratiehDepartment of Radiology, Biomedical Engineering Graduate Group, University of California Davis, Sacramento, CA, 95817, USA.
John M BooneDepartment of Radiology and Biomedical Engineering, Biomedical Engineering Graduate Group, University of California Davis, Sacramento, CA, 95817, USA.
University of California, Davis · US

Funding

Breast CT: Final Steps to TranslationR01CA181081 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BOONE, JOHN M · 2015 to 2019
$2.9M
NCI NIH HHS R01 CA181081
6 · The paper itself

Abstract

purposeThe purpose of this work was to develop and make available x-ray spectra for some of the most widely used digital mammography (DM), breast tomosynthesis (BT), and breast CT (bCT) systems in North America.

methodsThe Monte Carlo code MCNP6 was used to simulate minimally filtered (only beryllium) x-ray spectra at 8 tube potentials from 20 to 49 kV for DM/BT, and 9 tube potentials from 35 to 70 kV for bCT. Vendor-specific anode compositions, effective anode angles, focal spot sizes, source-to-detector distances, and beryllium filtration were simulated. For each 0.5 keV energy bin in all simulated spectra, the fluence was interpolated using cubic splines across the range of simulated tube potentials to produce spectra in 1 kV increments from 20 to 49 kV for DM/BT and from 35 to 70 kV for bCT. The HVL of simulated spectra with conventional filtration (at 35 kV for DM/BT and 49 kV for bCT) was used to assess spectral differences resulting from variations in: (a) focal spot size (0.1 and 0.3 mm IEC), (b) solid angle at the detector (i.e., small and large FOV size), and (c) geometrical specifications for vendors that employ the same anode composition.

resultsAveraged across all DM/BT vendors, variations in focal spot and FOV size resulted in HVL differences of 2.2% and 0.9%, respectively. Comparing anode compositions separately, the HVL differences for Mo (GE, Siemens) and W (Hologic, Philips, and Siemens) spectra were 0.3% and 0.6%, respectively. Both the commercial Koning and prototype "Doheny" (UC Davis) bCT systems utilize W anodes with a 0.3 mm focal spot. Averaged across both bCT systems, variations in FOV size resulted in a 2.2% difference in HVL. In addition, the Koning spectrum was slightly harder than Doheny with a 4.2% difference in HVL. Therefore to reduce redundancy, a generic DM/BT system and a generic bCT system were used to generate the new spectra reported herein. The spectral models for application to DM/BT were dubbed the Molybdenum, Rhodium, and Tungsten Anode Spectral Models using Interpolating Cubic Splines (MASMICS

conclusionsThe Mo, Rh, and W anode spectra for application in DM and BT (MASMICS

Indexed as

MammographyMonte Carlo MethodBreastBreast NeoplasmsFemaleHumansTungstenX-RaysTungstenbreast computed tomographybreast tomosynthesisdigital mammographyspectral modelingx-ray spectra

Identifiers

PMID28303582
PMCPMC5473362
OpenAlexW2596530362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.