Evidence map›Paper›PMID 28303572›Full record

ReviewThe Journal of physiology2017

Intracellular calcium release channels: an update.

Gaetano Santulli, Ryutaro Nakashima, Qi Yuan, Andrew R Marks

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Phosphorylation of RYR1 at SerScience signaling · 2025
    Article
  8. Review
  9. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. A deadly taste: linking bitter taste receptors and apoptosis.Apoptosis : an international journal on programmed cell death · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  20. Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gaetano SantulliThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.ORCID 0000-0001-7231-375X
Ryutaro NakashimaThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Qi YuanThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Andrew R MarksThe Wu Center for Molecular Cardiology, Columbia University, New York, NY, USA.
Columbia University Irving Medical Center · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5M
Intracellular calcium leak and muscle functionR01AR060037 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2010 to 2014
$1.7M
Targeting intracellular calcium leak as novel therapy for diabetesR00DK107895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SANTULLI, GAETANO · 2018 to 2020
$741k
Targeting intracellular calcium leak as novel therapy for diabetesK99DK107895 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTULLI, GAETANO · 2015 to 2016
$176k
NHLBI NIH HHS R01 HL061503NIAMS NIH HHS R01 AR060037NIDDK NIH HHS K99 DK107895NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R00 DK107895NIDDK NIH HHS R01HL061503
6 · The paper itself

Abstract

Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP

Indexed as

AnimalsBlood PressureCalciumDiabetes MellitusHeartHumansInositol 1,4,5-Trisphosphate ReceptorsMuscle, SkeletalMyocardiumRyanodine Receptor Calcium Release ChannelCalciumInositol 1,4,5-Trisphosphate ReceptorsRyanodine Receptor Calcium Release ChannelCalciumDiabetes mellitusexcitation-contraction couplingHeart failureHypertensionIntracellular calcium release channelsIP3RRyR

Identifiers

PMID28303572
PMCPMC5430224
OpenAlexW2595978963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.