Evidence map›Paper›PMID 28303522›Full record

ReviewProgress in biomaterials2017

Nanotechnology for the treatment of melanoma skin cancer.

Lucas B Naves, Chetna Dhand, Jayarama Reddy Venugopal, Lakshminarayanan Rajamani, Seeram Ramakrishna, Luis Almeida

Abstract readReview
In one paragraph

Review in Progress in biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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  7. 3D Computational Modeling of FeNanotechnology, science and applications · 2025
    Article
  8. Review
  9. Development of nanoemulgel of 5-Fluorouracil for skin melanoma using glycyrrhizin as a penetration enhancer.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  10. Article
  11. Article
  12. Poly(Pharmaceutics · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucas B NavesCAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil.
Chetna DhandAnti-Infectives Research Group, Singapore Eye Research Institute, Singapore, 169856, Singapore.
Jayarama Reddy VenugopalDepartment of Mechanical Engineering, Center for Nanofibers & Nanotechnology, National University of Singapore, Singapore, 117576, Singapore.
Lakshminarayanan RajamaniAnti-Infectives Research Group, Singapore Eye Research Institute, Singapore, 169856, Singapore.
Seeram RamakrishnaDepartment of Mechanical Engineering, Center for Nanofibers & Nanotechnology, National University of Singapore, Singapore, 117576, Singapore.
Luis AlmeidaCentre for Textile Science and Technology, University of Minho, Braga, Portugal. lalmeida@det.uminho.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. This literature review intends to elucidate the possibilities to treat melanoma skin cancer using hybrid nanofibers developed by advanced electrospinning process. In this review we have shown that the enhanced permeability and retention is the basis for using nanotechnology, aiming topical drug delivery. The importance of the detection of skin cancer in the early stages is directly related to non-metastatic effects and survival rates of melanoma cells. Inhibitors of protein kinase are already available in the market for melanoma treatment and are approved by the FDA; these agents are cobimetinib, dabrafenib, ipilimumab, nivolumab, trametinib, and vemurafenib. We also report a case study involving two different approaches for targeting melanoma skin cancer therapy, namely, magnetic-based core-shell particles and electrospun mats.

Indexed as

ChemotherapyDrug delivery systemsKinase inhibitorsSkin cancer therapyTopical delivery

Identifiers

PMID28303522
PMCPMC5433962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.