ArticleCell stress & chaperones2017
Enhanced resistance against Vibrio harveyi infection by carvacrol and its association with the induction of heat shock protein 72 in gnotobiotic Artemia franciscana.
Article in Cell stress & chaperones, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Probiotic potential of mangrove sediment-derived purple non-sulfur bacteria: effects on Artemia growth, vibrio resistance, and nutritional profile.World journal of microbiology & biotechnology · 2026Article
- Carvacrol as a one health-relevant antimicrobial agent: mechanistic insights on its impact on gnotobiotic Artemia and Vibrio campbellii interactions.Frontiers in immunology · 2026Article
- Heat shock proteins in farmed aquatic animals: advancing animal health and welfare management through building resilience.Frontiers in immunology · 2026Review
- Drought-Adapted Mediterranean Diet Plants: A Source of Bioactive Molecules Able to Give Nutrigenomic Effects per sè or to Obtain Functional Foods.International journal of molecular sciences · 2024Review
- Microbiomes in the context of developing sustainable intensified aquaculture.Frontiers in microbiology · 2023Review
- Heat Shock Proteins (Hsps) in Cellular Homeostasis: A Promising Tool for Health Management in Crustacean Aquaculture.Life (Basel, Switzerland) · 2022Review
- Determining the efficacy of gingerFrontiers in physiology · 2022Article
- Review
- Essential Oils Improve the Survival of Gnotobiotic Brine Shrimp (Frontiers in immunology · 2021Article
- Do acute hepatopancreatic necrosis disease-causing PirABEmerging microbes & infections · 2020Article
- Article
- Phloroglucinol Treatment Induces Transgenerational Epigenetic Inherited Resistance AgainstFrontiers in immunology · 2019Article
- Recombinant DnaK Orally Administered Protects Axenic European Sea Bass Against Vibriosis.Frontiers in immunology · 2019Article
- Phloroglucinol-Mediated Hsp70 Production in Crustaceans: Protection againstFrontiers in immunology · 2018Article
- Transcriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induction of HSP72 is a natural response of stressed organisms that protects against many insults including bacterial diseases in farm (aquatic) animals. It would therefore be of great health benefit to search for natural compounds that are clinically safe yet able to induce HSP72 in animals. The phenolic compound carvacrol, an approved food component, had been shown in in vitro study to act as a co-inducer of HSP72, enhancing HSP72 production only in combination with a bona fide stress compared to the compound alone. However, in vitro model systems do not completely represent an in vivo physiology. Here, using the well-established gnotobiotic Artemia model system, we determined whether carvacrol could induce HSP72 in vivo, whether this putative effect could generate resistance in Artemia against biotic/abiotic stress and also unraveled the mechanism behind the possible HSP72-inducing effect of carvacrol. The gnotobiotic system is crucial for such studies because it avoids the interference of any extraneous factors on host-compound interaction. Here, carvacrol was shown to be a potent HSP72 inducer. Induction of HSP72 was associated with the generation of resistance in Artemia larvae against subsequent lethal heat stress or pathogenic Vibrio harveyi. Our results also provided new insight on the mode of HSP72 inducing action of carvacrol, in which the initial generation of reactive molecule H
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