Trial reportClinical oral investigations2017
The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults.
Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02310308 (Effect of a Sugar-free Chewing Gum Containing Magnolia Bark Extract on the Development of Caries Lesions in Healthy Adult Volunteers), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Sugar-free Chewing Gum Containing Magnolia Bark Extract on the Development of Caries Lesions in Healthy Adult Volunteers: a Randomized Controlled Intervention Trial
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Caries prevention in permanent teeth - basic recommendations of the German S 3 guideline.Clinical oral investigations · 2026Guideline
- Specific effects of xylitol chewing gum on mutans streptococci levels, plaque accumulation and caries occurrence: a systematic review.BMC oral health · 2025Pooled it
- Effects of sugar-free polyol chewing gums on gingival inflammation: a systematic review.Clinical oral investigations · 2022Pooled it
- Effects of 4-week xylitol tablet intake on tongue microbiota composition in children: a single-arm pilot study.Microbiology spectrum · 2026Article
- Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026Review
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Diet and nutrition key factors for oral microbiota composition: a systematic review.Food & nutrition research · 2025Review
- Antibacterial Effectiveness and Periodontal Actions of Sugar-Free Chewing Gums Derived From Alcohol or Vegetables in Patients with Fixed Orthodontic Treatment: A Systematic Review.Clinical, cosmetic and investigational dentistry · 2025Review
- AnInternational journal of clinical pediatric dentistry · 2024Article
- How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective.NPJ biofilms and microbiomes · 2024Review
- Evaluation of caries risk assessment practices among dental practitioners in Guangzhou, China: a cross-sectional study.Frontiers in oral health · 2024Article
- Chronic graft-versus-host disease. Part II: Disease activity grading and therapeutic management.Journal of the American Academy of Dermatology · 2024Review
- A concise review of chewing gum as an anti-cariogenic agent.Frontiers in oral health · 2023Review
- Mechanical Vibration and Chewing Gum Methods in Orthodontic Pain Relief.Turkish journal of orthodontics · 2022Article
- Article
- The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials.Evidence-based complementary and alternative medicine : eCAM · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe caries preventive effect of long-term use (1 year) of low-dosage (2.5 g/die) of xylitol chewing gum in a high-caries-risk adult population was evaluated. MATERIALS AND
methodsIn this randomized clinical trial, 179 high-caries-risk adults were assigned to two experimental groups, xylitol and polyols. Caries status, salivary mutans streptococci (MS), and plaque pH were re-evaluated after 2 years from baseline in 66 xylitol and 64 polyol subjects. Outcomes (the net caries increment for initial, moderate, and extensive caries lesions and for the caries experience) were evaluated using the nonparametric Mann-Whitney U test.
resultsThe total caries experience increment was 1.25 ± 1.26 in the xylitol group and 1.80 ± 2.33 in the polyol group (p = 0.01). Subjects treated with xylitol chewing gums had a reduction of risk rate at tooth level of 23% with respect to those treated with polyols with a number needed to treat of 55 teeth. The area under the curve at pH 5.7 was statistically significantly lower (p = 0.02) during the experimental period in the xylitol group. A decrease of the concentration of salivary MS was noted in the xylitol group (p < 0.01).
conclusionsSubjects using the low-dose xylitol chewing gum showed a significantly lower increment of initial and extensive caries lesions and overall a lower increment of caries experience. CLINICAL RELEVANCE: One-year use of chewing gums provides an effective means for the prevention of caries disease. TRIAL REGISTRATION NUMBER: NCT02310308.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.