Trial reportPrevention science : the official journal of the Society for Prevention Research2018
Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems.
Trial report in Prevention science : the official journal of the Society for Prevention Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Pooled it
- Can Peer Acceptance and Perceptual Accuracy Impact the Effectiveness of Two Formats of a Preventative Intervention on Functional Subtypes of Aggression in Youth?Prevention science : the official journal of the Society for Prevention Research · 2025Trial
- Beyond Jacobson and Truax: Estimation of Clinical Significance Trajectories in the Coping Power Intervention Using Measurement Error-Corrected Multilevel Modeling.Behavior therapy · 2025Trial
- Intervention format and therapist-child agreement associated with therapeutic alliance and outcomes.Journal of consulting and clinical psychology · 2024Trial
- Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use.Development and psychopathology · 2022Trial
- Oxytocin-Receptor Gene Modulates Reward-Network Connection and Relationship with Empathy Performance.Psychology research and behavior management · 2023Article
- Substance Use Outcomes from Two Formats of a Cognitive-Behavioral Intervention for Aggressive Children: Moderating Roles of Inhibitory Control and Intervention Engagement.Brain sciences · 2021Article
- Social Emotional Learning Program Boosts Early Social and Behavioral Skills in Low-Income Urban Children.Frontiers in psychology · 2020Article
- Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.Journal of youth and adolescence · 2019Article
- Genomics, Big Data, and Broad Consent: a New Ethics Frontier for Prevention Science.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"Prevention science : the official journal of the Society for Prevention Research · 2018Article
- The Implications of Genetics for Prevention and Intervention Programming.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Cognitive Behavioral Intervention for Youth at Risk for Conduct Problems: Future Directions.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Coping Power is an evidence-based preventive intervention program for youth with aggressive behavior problems that has traditionally been delivered in small group formats. Because of concerns about iatrogenic effects secondary to aggregation of high risk youth, the current study examined whether genetic risk may moderate intervention outcome when youth were randomly assigned to group versus individual formats of an intervention. The oxytocin receptor gene (OXTR) has been associated with social behavior and may influence susceptibility to social reinforcement in general and deviant peer influence in particular. One variant of OXTR (rs2268493) was examined in 197 fourth-grade African-American children (64% male) who were randomly assigned to Group Coping Power or Individual Coping Power (Lochman et al. 2015). Longitudinal assessments of teacher- and parent-reported behavior were collected through a 1-year follow-up. Growth curve analyses revealed a genotype by delivery format interaction. Youth with the A/A genotype demonstrated reductions in externalizing problems over the course of the intervention regardless of intervention format. In contrast, carriers of the G allele receiving the group-based intervention showed little improvement during the intervention and a worsening of symptoms during the follow-up year, while those receiving the individual format demonstrated reductions in externalizing problems. Given the associations between this OXTR variant and social bonding, carriers of the G allele may be more sensitive to social rewards from deviant peers in the group setting. This study suggests that genetic factors may be useful in predicting which type of intervention will be most effective for a particular individual.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.