ReviewClinical rheumatology2017
Vitamin D deficiency as a risk factor for the development of autoantibodies in patients with ASIA and silicone breast implants: a cohort study and review of the literature.
Review in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- A case of autoimmune/inflammatory syndrome induced by adjuvants associated with breast augmentation: Coincidence or causality?JAAD case reports · 2025Article
- Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Breast Implants: A Case Report.Cureus · 2025Article
- Most Important Biomedical and Pharmaceutical Applications of Silicones.Materials (Basel, Switzerland) · 2025Review
- Biopolymers: Histopathologic Case Series of Patients with Permanent Synthetic Fillers Presenting Chronic Granulomatous Reaction and Hypercalcemia.Plastic and reconstructive surgery. Global open · 2024Article
- Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system.Immunologic research · 2024Article
- Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity-a case report and literature review.Frontiers in immunology · 2023Review
- Effects of Silicone Breast Implants on Human Cell Types In Vitro: A Closer Look on Host and Implant.Aesthetic plastic surgery · 2022Review
- Article
- Breast Implant Illness (BII): Real Syndrome or a Social Media Phenomenon? A Narrative Review of the Literature.Aesthetic plastic surgery · 2022Review
- Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease.Plastic and reconstructive surgery. Global open · 2022Article
- The Prevalence of Self-Reported Health Complaints and Health-Related Quality of Life in Women With Breast Implants.Aesthetic surgery journal · 2021Article
- Vitamin D supplementation: An innovative way to prevent asthma exacerbation in developing countries?Journal of Taibah University Medical Sciences · 2019Article
- Scleroderma-like syndrome in a woman with silicone breast implants - case report and critical review of the literature.Reumatologia · 2019Article
- Autoimmune/inflammatory syndrome induced by mineral oil: a health problem.Clinical rheumatology · 2018Review
- The ASIA syndrome: basic concepts.Mediterranean journal of rheumatology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of autoimmunity and/or autoimmune diseases is multifactorial. Vitamin D is one of the factors that might play a role. We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility. We measured vitamin D levels in 135 patients with ASIA in relation to silicone implant incompatibility and related findings to the presence of autoantibodies that are commonly used to diagnose systemic autoimmune diseases. Furthermore, we systematically reviewed the literature regarding vitamin D deficiency as a risk factor for the development of autoantibodies. Vitamin D measurements were available for analysis in 131 of 135 patients with ASIA in relation to SIIS. Twenty-three patients (18%) tested positive for autoantibodies, from which 18 patients (78%) had either a vitamin D deficiency or insufficiency (median vitamin D level 60.5 mmol/L), whereas five patients (22%) had sufficient vitamin D levels. The risk to develop autoantibodies was significantly increased in vitamin D deficient and/or insufficient patients [RR 3.14; 95% CI, 1.24-7.95; p = 0.009]. Reviewed literature suggested an association between vitamin D levels and the presence and/or titer levels of autoantibodies in different autoimmune diseases. From our current study and from our review of the literature, we conclude that vitamin D deficiency is related to the presence of autoantibodies. Whether vitamin D supplementation results in a decrease of autoimmunity needs to be studied prospectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.