SynthesisEuropean journal of nuclear medicine and molecular imaging2017
Consequences of radiopharmaceutical extravasation and therapeutic interventions: a systematic review.
Synthesis in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07174089 (New AI-based Technologies for Even Safer and More Precise Nuclear Medicine), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
New AI-based Technologies for Even Safer and More Precise Nuclear Medicine
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor ligands: version 1.0.European journal of nuclear medicine and molecular imaging · 2024Guideline
- Residual radiopharmaceutical activity in venous access devices during PET and SPECT imaging: a real-world clinical observational cohort study.EJNMMI reports · 2026Article
- Optimization of Gravity Infusion Protocols forPharmaceutics · 2026Article
- Technical Optimization Strategies for Amyloid PET Under Challenging Acquisition Conditions: A Comprehensive Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Acute complications of nuclear medicine: an emergency medicine perspective.EJNMMI research · 2026Review
- Gravity versus pump-driven infusion in targeted radionuclide therapy: a model-based dosimetric evaluation of extravasation.EJNMMI physics · 2026Article
- Review
- Real-time detection of extravasation events of diagnostic and therapeutic radiopharmaceuticals in oncology.PloS one · 2026Article
- Extravasation Frequency of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Treatment of [99mTc]Tc-hydroxy-diphosphonate ([99mTc]Tc-HDP) extravasation using hyaluronidase.Pharmacology research & perspectives · 2024Article
- Exploring Extravasation in Cancer Patients.Cancers · 2024Review
- Multicenter Evaluation of Frequency and Impact of Activity Infiltration in PET Imaging, Including Microscale Modeling of Skin-Absorbed Dose.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Safety injections of nuclear medicine radiotracers: towards a new modality for a real-time detection of extravasation events andEJNMMI physics · 2023Article
- Safety and Therapeutic Optimization of Lutetium-177 Based Radiopharmaceuticals.Pharmaceutics · 2023Review
- Adverse Clinical Events at the Injection Site Are Exceedingly Rare After Reported Radiopharmaceutical Extravasation in Patients UndergoingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Extravasation of Diagnostic Radiopharmaceuticals: A Wolf in Sheep's Clothing?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Transparency - a patient-centric view on radiopharmaceutical extravasations.Frontiers in nuclear medicine · 2023Article
- Extravasation of radiopharmaceuticals: Why report?Frontiers in nuclear medicine · 2023Article
- Radiopharmaceutical extravasations: a twenty year mini-review.Frontiers in nuclear medicine · 2023Review
- The decision to reimage following extravasation in diagnostic nuclear medicine.Frontiers in nuclear medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRadiopharmaceutical extravasation can potentially lead to severe soft tissue damage, but little is known about incidence, medical consequences, possible interventions, and effectiveness of these. The aims of this study are to estimate the incidence of extravasation of diagnostic and therapeutic radiopharmaceuticals, to evaluate medical consequences, and to evaluate medical treatment applied subsequently to those incidents.
methodsA sensitive and elaborate literature search was performed in Embase and PubMed using the keywords "misadministration", "extravasation", "paravascular infiltration", combined with "tracer", "radionuclide", "radiopharmaceutical", and a list of keywords referring to clinically used tracers (i.e. "Technetium-99m", "Yttrium-90"). Reported data on radiopharmaceutical extravasation and applied interventions was extracted and summarised.
resultsThirty-seven publications reported 3016 cases of diagnostic radiopharmaceutical extravasation, of which three cases reported symptoms after extravasation. Eight publications reported 10 cases of therapeutic tracer extravasation. The most severe symptom was ulceration. Thirty-four different intervention and prevention strategies were performed or proposed in literature.
conclusionsExtravasation of diagnostic radiopharmaceuticals is common.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.