Evidence map›Paper›PMID 28303228›Full record

ArticleActa pharmaceutica Sinica. B2017

Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from

Qiqing Cheng, Yuru Tong, Zihao Wang, Ping Su, Wei Gao, Luqi Huang

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Pan-Genome Analysis ofInternational journal of molecular sciences · 2025
    Article
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  3. Article
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  6. Isolation of 4-hydroxy 3-methyl 2-butenyl 4-diphosphate reductase (Physiology and molecular biology of plants : an international journal of functional plant biology · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Qiqing ChengSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; National Resource Center for Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Yuru TongSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; National Resource Center for Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China.
Zihao WangSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Ping SuSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; National Resource Center for Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei GaoSchool of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Luqi HuangNational Resource Center for Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing 100700, China.
Capital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNMacau University of Science and Technology · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR) is the last step key enzyme of the methylerythritol phosphate (MEP) pathway, synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate, which is important for regulation of isoprenoid biosynthesis. Here the full-length cDNA of

Indexed as

4-Hydroxy-3-methylbut-2-enyl diphosphate reductaseComplementationGene expressionTripterygium wilfordiiTriptolide

Identifiers

PMID28303228
PMCPMC5343154
OpenAlexW2581680794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.