ArticleFrontiers in microbiology2017
The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Machine learning prediction of long-term postoperative pneumonia risk: a retrospective cohort study.BMC medical informatics and decision making · 2026Article
- Lung and gut microbiota profiling in intensive care unit patients: a prospective pilot study.BMC infectious diseases · 2025Observational
- INTESTINAL EPITHELIAL-SPECIFIC OCCLUDIN DELETION WORSENS GUT PERMEABILITY AND SURVIVAL FOLLOWING SEPSIS.Shock (Augusta, Ga.) · 2025Article
- Skin, but not gut, microbial communities vary with social density in Antarctic fur seals.Frontiers in microbiology · 2025Article
- Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dysbiome and Its Role in Surgically Relevant Medical Disease.Surgical infections · 2023Review
- [Bacterial gut microbiota-key player in sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Review
- Exploring the Gut Microbiome in Myasthenia Gravis.Nutrients · 2022Review
- Interpersonal violence and painful bladder symptoms in community-dwelling midlife to older women.American journal of obstetrics and gynecology · 2022Article
- Natural experiments and long-term monitoring are critical to understand and predict marine host-microbe ecology and evolution.PLoS biology · 2021Article
- Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome.EBioMedicine · 2020Review
- Effects of heat stress on the gut health of poultry.Journal of animal science · 2020Review
- QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health.G3 (Bethesda, Md.) · 2020Article
- Review
- Gut integrity in critical illness.Journal of intensive care · 2019Review
- Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis.Frontiers in microbiology · 2019Review
- Influence of nutritional status on postoperative outcome in patients with colorectal cancer - the emerging role of the microbiome.Innovative surgical sciences · 2018Review
- Pesticides Could Alter Amphibian Skin Microbiomes and the Effects ofFrontiers in microbiology · 2018Article
- Altered Gut Microbiota in Myasthenia Gravis.Frontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mammals constantly face stressful situations, be it extended periods of starvation, sleep deprivation from fear of predation, changing environmental conditions, or loss of habitat. Today, mammals are increasingly exposed to xenobiotics such as pesticides, pollutants, and antibiotics. Crowding conditions such as those created for the purposes of meat production from animals or those imposed upon humans living in urban environments or during world travel create new levels of physiologic stress. As such, human progress has led to an unprecedented exposure of both animals and humans to accidental pathogens (i.e., those that have not co-evolved with their hosts). Strikingly missing in models of infection pathogenesis are the various elements of these conditions, in particular host physiologic stress. The compensatory factors released in the gut during host stress have profound and direct effects on the metabolism and virulence of the colonizing microbiota and the emerging pathobiota. Here, we address unanswered questions to highlight the relevance and importance of incorporating host stress to the field of microbial pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.