Evidence map›Paper›PMID 28303115›Full record

ArticleFrontiers in neurology2017

Evolution of Cerebral Ischemia Assessed by Amide Proton Transfer-Weighted MRI.

Guodong Song, Chunmei Li, Xiaojie Luo, Xuna Zhao, Shuai Zhang, Yi Zhang, Shanshan Jiang, Xianlong Wang, Yuhui Chen, Haibo Chen and 3 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guodong SongDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China.
Chunmei LiDepartment of Radiology, Beijing Hospital, National Center of Gerontology , Beijing , China.
Xiaojie LuoDepartment of Radiology, Beijing Hospital, National Center of Gerontology , Beijing , China.
Xuna ZhaoDepartment of Radiology, Johns Hopkins University , Baltimore, MD , USA.
Shuai ZhangDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China.
Yi ZhangDepartment of Radiology, Johns Hopkins University , Baltimore, MD , USA.
Shanshan JiangDepartment of Radiology, Johns Hopkins University , Baltimore, MD , USA.
Xianlong WangDepartment of Radiology, Zhujiang Hospital of Southern Medical University , Guangzhou , China.
Yuhui ChenDepartment of Neurology, Beijing Hospital, National Center of Gerontology , Beijing , China.
Haibo ChenDepartment of Neurology, Beijing Hospital, National Center of Gerontology , Beijing , China.
Tao GongDepartment of Neurology, Beijing Hospital, National Center of Gerontology , Beijing , China.
Jinyuan ZhouDepartment of Radiology, Johns Hopkins University , Baltimore, MD , USA.
Min ChenDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China.

Funding

Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7TR01EB009731 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2009 to 2016
$2.9M
Academic-Industrial Partnership to Develop Clinical Brain Cancer ImagingR01CA166171 · NCI · JOHNS HOPKINS UNIVERSITY · PI VAN ZIJL, PETER CM, ZHOU, JINYUAN · 2013 to 2017
$2.4M
US-China Collaborative Research on Stroke ImagingR01NS083435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2013 to 2015
$588k
NCI NIH HHS R01 CA166171NIBIB NIH HHS R01 EB009731NINDS NIH HHS R01 NS083435
6 · The paper itself

Abstract

Amide proton transfer-weighted (APTW) magnetic resonance imaging (MRI) has recently become a potentially important tool for evaluating acidosis in ischemic stroke. The purpose of this study was to evaluate the dynamic pH-related changes in the lesions in patients with ischemia. Thirty-nine patients with ischemic stroke (symptom onset to imaging time ranging 2 h-7 days) were examined with a 3.0-T MRI system. Patients were divided into four groups: at the hyperacute stage (onset time ≤ 6 h), at the acute stage (6 h < onset time ≤ 48 h), at the early subacute stage (48 h < onset time ≤ 96 h), and at the late subacute stage (96 h < onset time ≤ 168 h). The APTW signal intensities were quantitatively measured in multiple ischemic regions for each patient. Compared with the contralateral normal white matter, APTW signals were significantly lower in ischemic tissue for all four stages (

Indexed as

APT imagingchemical exchange saturation transfer imagingmagnetization transferpHstroke

Identifiers

PMID28303115
PMCPMC5332413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.