Evidence map›Paper›PMID 28303029›Full record

ArticleExperimental & molecular medicine2017

TMF and glycitin act synergistically on keratinocytes and fibroblasts to promote wound healing and anti-scarring activity.

Ga Young Seo, Yoongho Lim, Dongsoo Koh, Jung Sik Huh, Changlim Hyun, Young Mee Kim, Moonjae Cho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ga Young SeoDepartment of Biochemistry School of Medicine, Jeju National University, Jeju, Korea.
Yoongho LimDivision of Bioscience and Biotechnology, Konkuk University, Seoul, Korea.
Dongsoo KohDepartment of Applied Chemistry, Dongduk Women's University, Seoul, Korea.
Jung Sik HuhDepartment of Urology, School of Medicine, Jeju National University, Jeju, Korea.
Changlim HyunDepartment of Pathology, School of Medicine, Jeju National University, Jeju, Korea.
Young Mee KimDepartment of Biochemistry School of Medicine, Jeju National University, Jeju, Korea.
Moonjae ChoDepartment of Biochemistry School of Medicine, Jeju National University, Jeju, Korea.
Jeju National University · KRDongduk Women's University · KRKonkuk University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-β, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment.

Indexed as

AnimalsBurnsCell MovementCell ProliferationCells, CulturedCicatrixFemaleFibroblastsHumansIsoflavonesKeratinocytesLymphotoxin-alphaMaleMiceMice, Inbred C57BLMice, Inbred ICR4',6,7-trimethoxyisoflavoneglycitinIsoflavonesLymphotoxin-alpha

Identifiers

PMID28303029
PMCPMC5382558
OpenAlexW2596918664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.