ArticleScience (New York, N.Y.)2017
Aggregation of the Whi3 protein, not loss of heterochromatin, causes sterility in old yeast cells.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- PKM2 aggregation drives metabolism reprograming during aging process.Nature communications · 2024Article
- Article
- Phenotypic plasticity as a facilitator of microbial evolution.Environmental epigenetics · 2022Review
- Regulation of CLB6 expression by the cytoplasmic deadenylase Ccr4 through its coding and 3' UTR regions.PloS one · 2022Article
- Elongating RNA polymerase II and RNA:DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions.Nucleic acids research · 2021Article
- R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.PLoS genetics · 2021Article
- Article
- p53, A Victim of the Prion Fashion.Cancers · 2021Review
- Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020Review
- Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.International journal of molecular sciences · 2020Article
- Review
- A heat-sensitive Osh protein controls PI4P polarity.BMC biology · 2020Article
- Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae.Molecular cell · 2020Article
- Measuring the Replicative Lifespan of Saccharomyces cerevisiae Using the HYAA Microfluidic Platform.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Advances in quantitative biology methods for studying replicative aging inTranslational medicine of aging · 2020Article
- Cellular response to moderate chromatin architectural defects promotes longevity.Science advances · 2019Article
- Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging ofGenetics · 2019Article
- The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.Molecular cell · 2019Article
- Flavin-based metabolic cycles are integral features of growth and division in single yeast cells.Scientific reports · 2018Article
- Structural basis of the correct subunit assembly, aggregation, and intracellular degradation of nylon hydrolase.Scientific reports · 2018Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
In yeast, heterochromatin silencing is reported to decline in aging mother cells, causing sterility in old cells. This process is thought to reflect a decrease in the activity of the NAD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.