Evidence map›Paper›PMID 28302794›Full record

ArticleScience (New York, N.Y.)2017

DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation.

Xiaoyi Wang, Danesh Moazed

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. DNA Methylation ofBiology · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Minimal requirements for the epigenetic inheritance of engineered silent chromatin domains.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xiaoyi WangHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9373-8730
Danesh MoazedHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. danesh@hms.harvard.edu.ORCID 0000-0003-0321-6221

Funding

RNAi-mediated Targeting of Hetorochromatin AssemblyR01GM072805 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MOAZED, DANESH · 2005 to 2025
$6.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM072805
6 · The paper itself

Abstract

Epigenetic inheritance mechanisms play fundamental roles in maintaining cellular memory of gene expression states. In fission yeast, histone H3 lysine 9 (H3K9) is methylated (H3K9me) at heterochromatic domains. These domains can be epigenetically inherited when

Indexed as

Gene Expression Regulation, FungalGene SilencingBase SequenceBinding SitesChromosomes, FungalCyclic AMP Response Element-Binding ProteinDNA, FungalHistonesMethylationSchizosaccharomycesSchizosaccharomyces pombe ProteinsCyclic AMP Response Element-Binding ProteinDNA, FungalHistonesSchizosaccharomyces pombe Proteins

Identifiers

PMID28302794
PMCPMC5718040

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.