ArticleJournal of the American Society of Nephrology : JASN2017
Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival.
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In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A systematic review and meta-analysis of factors contributing to post-kidney transplant anemia and the effect of erythropoietin-stimulating agents.Systematic reviews · 2024Pooled it
- The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Trial
- Beyond traditional roles: vitamin D and erythropoietin as immune modulators in kidney diseases.Clinical kidney journal · 2026Review
- Erythropoietin prolongs graft survival in mice by counteracting trained immunity.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Erythropoietin in tissue engineering and beyond: a multifunctional macromolecule with emerging roles in organoids, immune modulation, and cancer research.Frontiers in bioengineering and biotechnology · 2026Review
- Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Review
- Non-hematopoietic erythropoietin splice variant is produced in the diseased human brain and confers neuroprotection.Frontiers in cellular neuroscience · 2025Article
- Increased Treg in Kidney Transplant Recipients With Erythrocytosis.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- What makes the kidney so tolerant?The Journal of clinical investigation · 2024Article
- Erythropoietin supplementation induces dysbiosis of the gut microbiota and impacts mucosal immunity in a non-diseased mouse model.Frontiers in immunology · 2024Article
- Anemia after kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2023Article
- Treatment Options for Anemia in Kidney Transplant Patients: A Review.Kidney medicine · 2023Review
- Erythropoietin in Glaucoma: From Mechanism to Therapy.International journal of molecular sciences · 2023Review
- Endogenous erythropoietin has immunoregulatory functions that limit the expression of autoimmune kidney disease in mice.Frontiers in immunology · 2023Article
- The immunomodulation role of Th17 and Treg in renal transplantation.Frontiers in immunology · 2023Review
- Injectable thermosensitive hydrogel loading erythropoietin and FK506 alleviates gingival inflammation and promotes periodontal tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Effect of Erythropoietin on Mononuclear Cells of the Bone Marrow and Spleen.Bulletin of experimental biology and medicine · 2022Article
- Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.International journal of molecular sciences · 2022Review
- Linking erythropoietin to Treg-dependent allograft survival through myeloid cells.JCI insight · 2022Article
- Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.Immunity · 2022Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 3 countries.
Carolina PurroyDepartment of Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute and.
Robert L FairchildDepartment of Immunology, The Cleveland Clinic, Cleveland, Ohio.
Toshiaki TanakaDepartment of Immunology, The Cleveland Clinic, Cleveland, Ohio.
William M BaldwinDepartment of Immunology, The Cleveland Clinic, Cleveland, Ohio.
Joaquin ManriqueNephrology Service, Complejo Hospitalario de Navarra, Pamplona, Spain.
Joren C MadsenCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Robert B ColvinCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Alessandro AlessandriniCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Bruce R BlazarDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota; and.
Miguel FribourgDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York.
Chiara DonadeiDepartment of Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute and.
Umberto MaggioreKidney and Pancreas Transplantation Unit, University Hospital of Parma, Parma, Italy.
Peter S HeegerDepartment of Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute and.
Paolo CravediDepartment of Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute and paolo.cravedi@mssm.edu.
Cleveland Clinic · USComplejo Hospitalario de Navarra · ESHarvard University · USIcahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USUniversity of Minnesota · USUniversity of Parma · IT
Funding
XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5MSurgery CoreP01AI087586 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI VALUJSKIKH, ANNA · 2010 to 2019
$17.2MProject 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MTolerance Strategies in Non-Human Primate Cardiac Allograft RecipientsU01AI094374 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2010 to 2016
$5.9MMixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantationU01AI131470 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2017 to 2022
$5.6MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MIn Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4MTranslational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5MComplement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3MComplement & T Cell Medicated Allograft RejectionR56AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2012 to 2012
$339kNHLBI NIH HHS P01 HL018646NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NIAID NIH HHS P01 AI087586NIAID NIH HHS P01 AI123086NIAID NIH HHS R01 AI071185NIAID NIH HHS R37 AI034495NIAID NIH HHS R56 AI071185NIAID NIH HHS T32 AI078892NIAID NIH HHS U01 AI094374NIAID NIH HHS U01 AI131470
Abstract
Although spontaneous kidney transplant acceptance/tolerance occurs in mice and occasionally in humans, mechanisms remain unclear. Herein we test the hypothesis that EPO, a hormone predominantly produced by the adult kidney, has immunomodulating properties that are required for spontaneous kidney graft acceptance.
Indexed as
Kidney TransplantationReceptor Cross-TalkAnimalsGraft SurvivalHumansMiceProspective StudiesReceptors, ErythropoietinT-Lymphocytes, RegulatoryReceptors, Erythropoietinacute allograft rejectionerythropoietinRegulatory T celltransplantation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.