Evidence map›Paper›PMID 28302748›Full record

ArticleDevelopment (Cambridge, England)2017

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.

Grace Hwang, Fengyun Sun, Marilyn O'Brien, John J Eppig, Mary Ann Handel, Philip W Jordan

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
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  5. International journal of molecular sciences · 2023
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  6. Review
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  19. Article
  20. Conditional Mutation of SMC5 in Mouse Embryonic Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grace HwangDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Fengyun SunThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Marilyn O'BrienThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0001-6634-0815
John J EppigThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Mary Ann HandelThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Philip W JordanDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA pjordan8@jhu.edu.ORCID 0000-0003-4890-2647

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Anna Karolina Palucka · 1985 to 2026
$61.9M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
CELL CYCLE REGULATION DURING SPERMATOGENESISR01HD033816 · NICHD · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HANDEL, MARY ANN · 1996 to 2016
$4.7M
Regulation of microtubule organizing centers during mammalian gametogenesisR01GM117155 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Philip W Jordan · 2016 to 2026
$4.3M
The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic FidelityR00HD069458 · NICHD · JOHNS HOPKINS UNIVERSITY · PI JORDAN, PHILIP W · 2013 to 2015
$613k
The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic FidelityK99HD069458 · NICHD · JACKSON LABORATORY · PI JORDAN, PHILIP W · 2011 to 2012
$180k
NCI NIH HHS P30 CA034196NCI NIH HHS T32 CA009110NICHD NIH HHS K99 HD069458NICHD NIH HHS R00 HD069458NICHD NIH HHS R01 HD033816NIGMS NIH HHS R01 GM117155
6 · The paper itself

Abstract

SMC complexes include three major classes: cohesin, condensin and SMC5/6. However, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oogenesis have not previously been examined. In mouse oocytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes along chromosome arms during meiosis. The infertility phenotypes of females with a

Indexed as

Chromosome SegregationMeiosisAdenosine TriphosphatasesAgingAneuploidyAnimalsBlastocystCell Cycle ProteinsChromosomes, MammalianDNA-Binding ProteinsFemaleFertilization in VitroGenotyping TechniquesHeterochromatinInfertility, FemaleIntegrasesAdenosine TriphosphatasesCell Cycle Proteinscondensin complexesCre recombinaseDNA-Binding ProteinsHeterochromatinIntegrasesMultiprotein ComplexesSMC5 protein, mouseSMC6 protein, mouseAneuploidyChromosome segregationCohesinCondensinMeiosisSMC5/6

Identifiers

PMID28302748
PMCPMC5450844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.