ArticleGenome research2017
Time-dependent genetic effects on gene expression implicate aging processes.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Dynamic neuro-immune regulation of psychiatric risk loci in human neurons.Nature communications · 2026Article
- Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progression.medRxiv : the preprint server for health sciences · 2026Article
- Genetic susceptibility shaped by biological state: beyond gene-environment interaction.Frontiers in genetics · 2026Review
- Incorporating transcriptomic data into genomic prediction models to improve the prediction accuracy of phenotypes of efficiency traits.Genetics, selection, evolution : GSE · 2025Article
- RETROSPECTIVE VARYING COEFFICIENT ASSOCIATION ANALYSIS OF LONGITUDINAL BINARY TRAITS: APPLICATION TO THE IDENTIFICATION OF GENETIC LOCI ASSOCIATED WITH HYPERTENSION.The annals of applied statistics · 2024Article
- Urgent needs of caregiving in ageing populations with Alzheimer's disease and other chronic conditions: Support our loved ones.Ageing research reviews · 2023Review
- Methods and Insights from Single-Cell Expression Quantitative Trait Loci.Annual review of genomics and human genetics · 2023Review
- Adding gene transcripts into genomic prediction improves accuracy and reveals sampling time dependence.G3 (Bethesda, Md.) · 2022Article
- Does Modulation of an Epigenetic Clock Define a Geroprotector?Advances in geriatric medicine and research · 2022Article
- Multi-omics analysis reveals the host-microbe interactions in aged rhesus macaques.Frontiers in microbiology · 2022Article
- Breaking the aging epigenetic barrier.Frontiers in cell and developmental biology · 2022Review
- Cellular reprogramming and epigenetic rejuvenation.Clinical epigenetics · 2021Review
- Epigenetic age prediction.Aging cell · 2021 · on this mapReview
- Dream: powerful differential expression analysis for repeated measures designs.Bioinformatics (Oxford, England) · 2021Article
- A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.Disease models & mechanisms · 2021Article
- Longitudinal profiling of the blood transcriptome in an African green monkey aging model.Aging · 2020Article
- Estimation of dynamic SNP-heritability with Bayesian Gaussian process models.Bioinformatics (Oxford, England) · 2020Article
- DNA methylation QTL analysis identifies new regulators of human longevity.Human molecular genetics · 2020Article
- Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a PlateletCirculation research · 2020Article
- A characterization of cis- and trans-heritability of RNA-Seq-based gene expression.European journal of human genetics : EJHG · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Gene expression is dependent on genetic and environmental factors. In the last decade, a large body of research has significantly improved our understanding of the genetic architecture of gene expression. However, it remains unclear whether genetic effects on gene expression remain stable over time. Here, we show, using longitudinal whole-blood gene expression data from a twin cohort, that the genetic architecture of a subset of genes is unstable over time. In addition, we identified 2213 genes differentially expressed across time points that we linked with aging within and across studies. Interestingly, we discovered that most differentially expressed genes were affected by a subset of 77 putative causal genes. Finally, we observed that putative causal genes and down-regulated genes were affected by a loss of genetic control between time points. Taken together, our data suggest that instability in the genetic architecture of a subset of genes could lead to widespread effects on the transcriptome with an aging signature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.