ReviewJournal of applied physiology (Bethesda, Md. : 1985)2018
Brown and beige adipose tissues: phenotype and metabolic potential in mice and men.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Potential roles of β3-adrenergic receptor in heart rate regulation via sinus node activity and local adipocyte metabolism.The journal of physiological sciences : JPS · 2026Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Molecular and Neural Mechanisms of Temperature Preference Rhythm inJournal of biological rhythms · 2023Review
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue.International journal of molecular sciences · 2022Article
- Ether Lipids in Obesity: From Cells to Population Studies.Frontiers in physiology · 2022Review
- Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis.Metabolites · 2021Review
- Bone Marrow Adipocytes-Role in Physiology and Various Nutritional Conditions in Human and Animal Models.Nutrients · 2021Review
- Adipose ABHD6 regulates tolerance to cold and thermogenic programs.JCI insight · 2020Article
- Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [Molecular imaging and biology · 2020Article
- Importance of adipocyte browning in the evolution of endothermy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Fatty Acid Metabolite Profiling Reveals Oxylipins as Markers of Brown but Not Brite Adipose Tissue.Frontiers in endocrinology · 2020Article
- Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content.Scientific reports · 2019Article
- Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control.Journal of cachexia, sarcopenia and muscle · 2018Article
- Fucoxanthin and Its Metabolite Fucoxanthinol Do Not Induce Browning in Human Adipocytes.Journal of agricultural and food chemistry · 2017Article
- Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.Scientific reports · 2017Article
- A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
With the recent rediscovery of brown fat in adult humans, our outlook on adipose tissue biology has undergone a paradigm shift. While we attempt to identify, recruit, and activate classic brown fat stores in humans, identification of beige fat has also raised the possibility of browning our white fat stores. Whether such transformation of human white fat depots can be achieved to enhance the whole body oxidative potential remains to be seen. Evidence to date, however, largely points toward a major oxidative role only for classic brown fat depots, at least in rodents. White fat stores seem to provide the main fuel for sustaining thermogenesis via lipolysis. Interestingly, molecular markers consistent with both classic brown and beige fat identity can be observed in human supraclavicular depot, thereby complicating the discussion on beige fat in humans. Here, we review the recent advances made in our understanding of brown and beige fat in humans and mice. We further provide an overview of their plausible physiological relevance to whole body energy metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.