Evidence map›Paper›PMID 28302254›Full record

SynthesisDeutsches Arzteblatt international2017

Cognitive Reserve and the Risk of Postoperative Cognitive Dysfunction.

Insa Feinkohl, Georg Winterer, Claudia D Spies, Tobias Pischon

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Deutsches Arzteblatt international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04191642 completednot on this mapstarted 2019, after this paper: background citation

Correlation of NLRP3 With Cognitive Dysfunction Early After Heart Valve

TypeobservationalSponsorGeneral Hospital of Ningxia Medical UniversityRan2019 to 2021Enrolled75ConditionsInflammasomes, Cognitive Dysfunction, Pyrin Domain-Containing 3 Protein, Postoperative Complications
NCT05378659 unknown statusnot on this mapstarted 2021, after this paper: background citation

Neuroinflammation and Alzheimer's Pathology in Post-operative Cognitive Dysfunction: A Pilot Study

TypeobservationalSponsorUniversity of Tennessee Graduate School of MedicineRan2021 to 2022Enrolled120ConditionsPost-Operative Confusion, Neuroinflammatory Response, Alzheimer DiseaseArmsMontreal Cognitive Assessment, Stroop Test, 4AT Delirium, Grooved Pegboard, NACC Cognitive Battery
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Insa FeinkohlMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin-Buch; Charité - Universitätsmedizin Berlin; MDC/BIH Biobank, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin-Buch and Berlin Institute of Health (BIH), Berlin.
Georg Winterer
Claudia D Spies
Tobias Pischon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-operative cognitive dysfunction (POCD) occurs in 10 to 54% of older patients during the first few weeks after surgery, but little is known about risk factors predisposing to POCD.

methodsSystematic literature review and meta-analysis of cognitive reserve indicators and POCD risk.

resultsFifteen studies on 5104 patients were included. Follow-up periods spanned 1 day to 6 months. Educational level was the most commonly assessed cognitive reserve indicator, and a longer time spent in education was associated with a reduced risk of POCD (relative risk [RR] per year increment 0.90; 95% confidence interval: [0.87; 0.94]), i.e. each year increase in education was associated with a 10% reduced risk. Similar findings were made for some analyses on education as a categorical predictor (high school versus further/higher education, RR 1.71, [1.30; 2.25]; lower than high school versus further/higher education, RR 1.69, [1.17; 2.44]) though risk was equivalent for patients with high school education and those with lower than high school education (RR 1.02; [0.78; 1.32]).

conclusionPatients with a relatively higher level of education are at reduced risk of POCD. Risk stratification of surgical patients according to educational level may prove useful.

Indexed as

Cognitive ReservePostoperative ComplicationsAdultCognitive DysfunctionDeliriumFemaleHumansMaleNeuropsychological Tests

Identifiers

PMID28302254
PMCPMC5359463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.