Evidence map›Paper›PMID 28302216›Full record

ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2017

[Association of Indoor Air Pollution, Single Nucleotide Polymorphism of HIF-1α Gene with Susceptibility to Lung Cancer in Han Population in Fujian Province].

Fei He, Qi Qi, Xu Li, Rendong Xiao, Qiuping Xu, Weimin Xiong, Zhiqiang Liu, Lin Cai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Environmental and occupational determinants of lung cancer.Translational lung cancer research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fei HeDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Qi QiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Xu LiDepartment of Thoracic Surgery, the First Clinical Medical College of Fujian Medical University, Fuzhou 350108, China.
Rendong XiaoDepartment of Thoracic Surgery, the First Clinical Medical College of Fujian Medical University, Fuzhou 350108, China.
Qiuping XuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Weimin XiongDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Zhiqiang LiuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Lin CaiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoxia inducible factor-1α (HIF-1α) is associated with the progression and metastasis of lung cancer. There are, however, few studies on the relationship between the single nucleotide polymorphisms of HIF-1α and susceptibility to lung cancer. Therefore, we aimed to investigate the relationship between indoor air pollution, HIF-1α rs2057482, and the susceptibility to primary lung cancer of the Fujian Han population.

methodsThe present study is a hospital-based case-control study. We recruited 1,096 lung cancer and 1,110 controls that were admitted to the Department of Thoracic Surgery of the First Affiliated Hospital and Union Hospital of Fujian Medical University and Fuzhou General Hospital of Nanjing Military Region from January 2006 to December 2012. The primary lung cancer cases were identified via pathological methods. Both case and control groups received questionnaires. Genotyping of HIF-1α gene rs2057482 locus polymorphism in all subjects were analyzed by MALDI-TOF-MS technique.

resultsIndividuals who carried the T-genotype of HIF-1α rs2057482 were more susceptible to small cell carcinoma (odds ratio of 1.725, 95%CI: 1.047-2.842). After adjusting for general and lung cancer-related factors, we found that in the co-dominant genetic model, rs2057482 TT carriers were 2.195 times more likely to develop lung cancer than CC carriers (95%CI: 1.038-4.463) in the population that were exposed to passive smoking. In the dominant genetic model, the risk of lung cancer was 1.911 times (95%CI: 1.121-3.258) that in the carriers of the rs2057482 T allele with a family history of cancer. In the recessive genetic model, rs2057482 TT carriers had a 0.159-fold increased risk of lung cancer (95%CI: 0.028-0.920) than TC+CC carriers in people with a history of lung disease. In the additive genetic model, the risk of lung cancer in rs2057482 TC+TT carriers was 1.542 times (95%CI: 1.107-2.340) that in the CC family of people with a family history of cancer.

conclusionsHIF-1α rs2057482 may be associated with lung cancer susceptibility.
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Indexed as

Polymorphism, Single NucleotideAir Pollution, IndoorCase-Control StudiesChinaEthnicityFemaleGenetic Predisposition to DiseaseHumansHypoxia-Inducible Factor 1, alpha SubunitLung NeoplasmsMaleHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID28302216
PMCPMC5973304
OpenAlexW2605656852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.