Trial reportBMC pediatrics2017
Thermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values.
Trial report in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.European journal of anaesthesiology · 2019Trial
- Real-time assessment of temperature sensitivity, pain processing, and pain behavior across the lifespan: Integrating stimulus data, contact force, and subjective ratings.Behavior research methods · 2026Article
- Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study.Pain reports · 2026Article
- Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions.Bioactive materials · 2026Review
- Long-term impact of necrotizing enterocolitis on somatosensory function in preterm born children.Pediatric research · 2026Article
- Small fiber neuropathy in pediatric female heterozygotes of Fabry disease: a twin case report.BMC pediatrics · 2025Article
- The role of puberty in experimental pain sensitivity in healthy adolescent girls.Pain reports · 2025Article
- Painfully Sensitive: How Sensory Processing Sensitivity Affects Healthy Adolescents' Perception of Pain.Journal of pain research · 2025Article
- Quantitative sensory testing for assessment of somatosensory function in children and adolescents: a scoping review.Pain reports · 2024Article
- Pain during the first year after scoliosis surgery in adolescents, an exploratory, prospective cohort study.Frontiers in pediatrics · 2024Article
- Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders.Frontiers in neurology · 2022Article
- Sensory Function and Psychological Factors in Children With Complex Regional Pain Syndrome Type 1.Journal of child neurology · 2021Article
- Diabetic neuropathy in children and youth: New and emerging risk factors.Pediatric diabetes · 2021Review
- Current View of Diagnosing Small Fiber Neuropathy.Journal of neuromuscular diseases · 2021Review
- Thermal Perceptual Thresholds are typical in Autism Spectrum Disorder but Strongly Related to Intra-individual Response Variability.Scientific reports · 2019Article
- Body regional heat pain thresholds using the method of limit and level: a comparative study.European journal of applied physiology · 2019Article
- Temporal relationship between perceptual and physiological events triggered by nociceptive heat stimuli.Scientific reports · 2019Article
- TRPM2 and warmth sensation.Pflugers Archiv : European journal of physiology · 2018Review
- Method-of-limits; Cold and warm perception thresholds at proximal and distal body regions.Clinical neurophysiology practice · 2018Article
- Real-time evaluation of an automated computer vision system to monitor pain behavior in older adults.Journal of rehabilitation and assistive technologies engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative sensory testing (QST) is often used to measure children's and adults' detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often applied to determine thermal detection and pain thresholds. As comparisons between studies are hampered by the different testing protocols used, we aimed to present a standard protocol and reference values for thermal detection- and pain thresholds in children.
methodsOur standard testing protocol includes reaction time dependent and independent tests and takes about 14-18 min to complete. Reference values were obtained from a sample of 69 healthy term born children and adolescents with a median age of 11.2 years (range 8.2 to 17.9 years old). Seventy-one children were recruited and data of 28 males and 41 females was obtained correctly. We studied possible age and sex differences.
resultsThis study provides Dutch reference values and presents a standard quantitative sensory testing protocol for children with an age from 8 years onwards. This protocol appeared to be feasible, since only two out of 71 participants were not able to correctly complete the protocol due to attention deficits and were therefore excluded. We found some significant age and sex differences: females were statistically significantly more sensitive for both cold and heat pain compared to males, and the youngest children (8-9 years old) were less sensitive to detect a warm stimulus. The youngest children tend to be more sensitive to heat pain in comparison to older participants, although the difference was not statistically significant.
conclusionsWe present a feasible thermal quantitative sensory testing protocol for children and reference values that are easy to interpret and may serve as normative values for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.