ReviewOrphanet journal of rare diseases2017
Maximum inspiratory pressure as a clinically meaningful trial endpoint for neuromuscular diseases: a comprehensive review of the literature.
Review in Orphanet journal of rare diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Weaning from mechanical ventilation in people with neuromuscular disease: a systematic review.BMJ open · 2021Pooled it
- Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravis post-hospitalization- a randomized controlled trial.BMC pulmonary medicine · 2025Trial
- Respiratory muscle training in late-onset Pompe disease: Results of a sham-controlled clinical trial.Neuromuscular disorders : NMD · 2020Trial
- Assessing airway clearance dysfunction in Friedreich's ataxia: A focus on peak cough flow.Journal of neuromuscular diseases · 2026Article
- Pulmonary Function Tests as Predictors of Successful Tracheostomy Decannulation: A 60-Day Prospective Study.International journal of medical sciences · 2026Observational
- Predictors of respiratory decline in neuromuscular disorders.Respiratory medicine · 2026Review
- Maximal inspiratory diaphragmatic ultrasound predicts postoperative pulmonary complications after upper abdominal surgery.Annals of intensive care · 2025Article
- Twelve weeks of respiratory muscle training enhance respiratory function in CrossFitBMC sports science, medicine & rehabilitation · 2025Article
- A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways.Paediatric drugs · 2025Review
- Evaluation of Inspiratory Muscle Training Effect Compared With Diaphragmatic Breathing in Respiratory Parameters in Amyotrophic Lateral Sclerosis Patients: A Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2025Article
- Respiratory Function and Information Processing Speed in Coal Power Plant Workers: Moderating Effects of Physical Activity and Sedentary Behavior.Risk management and healthcare policy · 2025Article
- Respiratory Muscle Strength Correlation with Functional Capacity, Quality of Life, Demographics and Co-morbidities in Stroke and Spinal Cord Injury.Journal of musculoskeletal & neuronal interactions · 2024Article
- The role of maximal inspiratory pressure on functional performance in adults with heart failure.ESC heart failure · 2024Article
- Evaluating Respiratory Muscle Strength in Sarcopenia Screening among Older Men in South Korea: A Retrospective Analysis.The world journal of men's health · 2024Article
- Insomnia and sleep-disordered breathing in FKRP-related limb-girdle muscular dystrophy R9. The Norwegian LGMDR9 cohort study (2020).Journal of neurology · 2024Article
- A preliminary exploration of the regression equation for performance in amateur half-marathon runners: a perspective based on respiratory muscle function.Frontiers in physiology · 2024Article
- Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Observational
- Ultrasonic Evaluation of Diaphragm in Patients with Systemic Sclerosis.Journal of personalized medicine · 2023Article
- Biomarkers: Role and Scope in Neurological Disorders.Neurochemical research · 2023Review
- Peak Inspiratory Flow for Screening of Inspiratory Muscle Weakness in Neuromuscular Disease.Lung · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory muscle strength is a proven predictor of long-term outcome of neuromuscular disease (NMD), including amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and spinal muscular atrophy. Maximal inspiratory pressure (MIP), a sensitive measure of respiratory muscle strength, one of several useful tests of respiratory muscle strength, is gaining interest as a therapeutic clinical trial endpoint for NMD. In this comprehensive review we investigate the use of MIP as a measure of respiratory muscle strength in clinical trials of therapeutics targeting respiratory muscle, examine the correlation of MIP with survival, quality of life, and other measures of pulmonary function, and outline the role of MIP as a clinically significantly meaningful outcome measure. Our analysis supports the utility of MIP for the early evaluation of respiratory muscle strength, especially of the diaphragm, in patients with NMD and as a surrogate endpoint in clinical trials of therapies for NMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.