Evidence map›Paper›PMID 28302109›Full record

ArticleRespiratory research2017

Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers.

Tricia D LeVan, Lynette M Smith, Art J Heires, Ted R Mikuls, Jane L Meza, Lisa A Weissenburger-Moser, Debra J Romberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tricia D LeVanDepartment of Epidemiology, University of Nebraska Medical Center, 985910, Omaha, NE, 68198-5910, USA. tlevan@unmc.edu.
Lynette M SmithDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Art J HeiresDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Ted R MikulsDepartment of Internal Medicine and Veterans Nebraska Western Iowa Healthcare System, Omaha, NE, USA.
Jane L MezaDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Lisa A Weissenburger-MoserDepartment of Epidemiology, University of Nebraska Medical Center, 985910, Omaha, NE, 68198-5910, USA.
Debra J RombergerDepartment of Internal Medicine and Veterans Nebraska Western Iowa Healthcare System, Omaha, NE, USA.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Molecular Genetics of Pathogen Recognition Receptors in COPDI01CX000434 · VA · OMAHA VA MEDICAL CENTER · PI LEVAN, TRICIA D · 2011 to 2014
–
CSRD VA I01 CX000434NIOSH CDC HHS U54 OH010162
6 · The paper itself

Abstract

backgroundAgricultural environments are contaminated with organic dusts containing bacterial components. Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-negative lipopolysaccharide; however, its association with respiratory disease among agricultural workers is unknown. The objective of this study was to determine if serum soluble CD14 (sCD14) levels are associated with lung function among agricultural workers and if this association is modified by genetic variants in CD14.

methodsThis cross-sectional study included 584 veterans with >2 years of farming experience and that were between the ages of 40 and 80 years. Participants underwent spirometry and were genotyped for four tagging CD14 polymorphisms (CD14/-2838, rs2569193; CD14/-1720, rs2915863; CD14/-651, rs5744455; and CD14/-260, rs2569190). Serum sCD14 was assayed by ELISA.

resultsSubjects were 98% white males with a mean age 64.5 years. High soluble CD14 levels (> median sCD14) were associated decreased lung function (FEV

conclusionCD14 haplotypes and sCD14 are important mediators of lung function among those with COPD in this occupationally-exposed population.

Indexed as

AdultAgedAged, 80 and overAgricultural Workers' DiseasesFarmersFemaleGenetic Predisposition to DiseaseHaplotypesHumansLipopolysaccharide ReceptorsLungMaleMiddle AgedMutationNebraskaPolymorphism, Single NucleotideLipopolysaccharide ReceptorsAgricultureCD14COPDLung functionPolymorphism

Identifiers

PMID28302109
PMCPMC5353891
OpenAlexW2595814950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.