Evidence map›Paper›PMID 28301764›Full record

ReviewAnnual review of clinical psychology2017

Reward Processing, Neuroeconomics, and Psychopathology.

David H Zald, Michael T Treadway

Registry-linked trialAbstract readReview
In one paragraph

Review in Annual review of clinical psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06472622 (Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort), which is not on this map. Cited by 99 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06472622 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

TypeinterventionalSponsorNational Institute of Neurological Disorders and Stroke (NINDS)Ran2025 to 2034Enrolled47ConditionsFatigue Syndrome, ChronicArmsThermal Pain Stimulation, Physical Effort Stimulation
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Decisional reference point pathology: A cognitive mechanism for and a correlate of major depressive disorder in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David H ZaldDepartment of Psychology and Department of Psychiatry, Vanderbilt University, Nashville, Tennessee 37240; email: david.zald@vanderbilt.edu.
Michael T TreadwayDepartment of Psychology, Emory University, Atlanta, Georgia 30322; email: mtreadway@emory.edu.

Funding

RDoC Constructs: Neural Substrates, Heritability, and Relation to PsychopathologyR01MH098098 · NIMH · VANDERBILT UNIVERSITY · PI LAHEY, BENJAMIN B, ZALD, DAVID HAROLD · 2012 to 2015
$4.4M
Dynamics of Inflammation and its Blockade on Motivational Circuitry in DepressionR01MH108605 · NIMH · EMORY UNIVERSITY · PI TREADWAY, MICHAEL TILGHMAN · 2016 to 2020
$2.1M
NIMH NIH HHS R01 MH098098NIMH NIH HHS R01 MH108605
6 · The paper itself

Abstract

Abnormal reward processing is a prominent transdiagnostic feature of psychopathology. The present review provides a framework for considering the different aspects of reward processing and their assessment, and highlights recent insights from the field of neuroeconomics that may aid in understanding these processes. Although altered reward processing in psychopathology has often been treated as a general hypo- or hyperresponsivity to reward, increasing data indicate that a comprehensive understanding of reward dysfunction requires characterization within more specific reward-processing domains, including subjective valuation, discounting, hedonics, reward anticipation and facilitation, and reinforcement learning. As such, more nuanced models of the nature of these abnormalities are needed. We describe several processing abnormalities capable of producing the types of selective alterations in reward-related behavior observed in different forms of psychopathology, including (mal)adaptive scaling and anchoring, dysfunctional weighting of reward and cost variables, competition between valuation systems, and reward prediction error signaling.

Indexed as

Economics, BehavioralRewardHumansMental Disordersaddictionanhedoniacomputational psychiatrydopaminemajor depressionprediction error

Identifiers

PMID28301764
PMCPMC5958615

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.