ArticlePloS one2017
Cerebral ultrasound abnormalities in preterm infants caused by late-onset sepsis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Sensory processing and motor development in term infants following late-onset neonatal sepsis-a cross-sectional study.European journal of pediatrics · 2025Observational
- Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Neurosonography: Shaping the future of neuroprotection strategies in extremely preterm infants.Heliyon · 2024Review
- Monoclonal antibodies effectively potentiate complement activation and phagocytosis ofFrontiers in immunology · 2022Article
- Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis.European journal of pediatrics · 2019Article
- The prognostic value of NIRS in preterm infants with (suspected) late-onset sepsis in relation to long term outcome: A pilot study.PloS one · 2019Observational
- Beyond sepsis: Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity.Virulence · 2018Review
- New Threats from an Old Foe: Methicillin-Resistant Staphylococcus aureus Infections in Neonates.Neonatology · 2018Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study describes cerebral ultrasound abnormalities caused by late-onset sepsis (LOS) in very preterm infants with a gestational age of < 32 weeks and/or birthweight < 1500 grams.
methodsThe prospective study ("INFANT study") included 117 preterm infants with suspected LOS. Proven LOS was defined as a positive blood culture after 72 hours of life. In case of coagulase-negative staphylococci an elevated C-reactive protein was additionally required to establish proven LOS. Patients were identified as proven LOS and patients with only clinical symptoms of LOS. Cerebral ultrasound images were obtained in the first week after birth, during/after LOS and before discharge. Cerebral findings were divided in no/minor and major abnormalities.
resultsEighty-six preterm infants had proven LOS and 31 preterm infants had only clinical signs of LOS. Four infants were excluded because pre-existing major brain abnormalities. No significant differences (p = 0.624) for incidence of major brain abnormalities on cerebral ultrasound were found.
conclusionNo differences were revealed in prevalence of major brain abnormalities between the groups with proven LOS and with clinical signs of LOS. Both infants with a gram negative sepsis developed major brain abnormalities, whereas only two of 66 preterm infants coagulase-negative staphylococci sepsis developed major brain abnormalities.
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