Evidence map›Paper›PMID 28301471›Full record

ArticlePloS one2017

Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient.

Ali Bashir, Oliver Attie, Mitchell Sullivan, Robert Sebra, Kavindra V Singh, Deena Altman, Theodore Pak, Jayeeta Dutta, Kieran Chacko, Elizabeth Webster and 7 more

Abstract readCase Reports
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. VanA-Enterococcus faecalis in Poland: hospital population clonal structure and vanA mobilome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Article
  2. Review
  3. Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ali BashirInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID http://orcid.org/0000-0002-5240-9604
Oliver AttieInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Mitchell SullivanInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Robert SebraInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Kavindra V SinghDivision of Infectious Diseases, Department of Medicine, The University of Texas Medical School, Houston, TX.
Deena AltmanDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Theodore PakInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Jayeeta DuttaInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Kieran ChackoInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Elizabeth WebsterInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Martha LewisInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Camille HamulaDepartment of Pathology, Icahn School of Medicine, New York, NY.
Kristin W Delli CarpiniLiveOnNY, New York, NY.
Barbara E MurrayDivision of Infectious Diseases, Department of Medicine, The University of Texas Medical School, Houston, TX.
Andrew KasarskisInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Harm van BakelInstitute and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Shirish HuprikarDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Funding

Investigating genomic factors and microbiome features that impact CDI transmission and prognosisR01AI119145 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASHIR, ALI M, VAN BAKEL, HARM · 2015 to 2019
$4.2M
MSHS Translational Science HubKL2TR001435 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSKOWITZ, ALAN J · 2015 to 2019
$3.8M
Multiscale analysis of immune profiling data from dengue and chikungunya virus infections in humansF30AI122673 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAK, THEODORE ROBERTSON · 2016 to 2018
$132k
NCATS NIH HHS KL2 TR001435NIAID NIH HHS F30 AI122673NIAID NIH HHS R01 AI119145
6 · The paper itself

Abstract

In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing identified that donor and recipient VRE isolates were highly similar when compared to time-matched hospital isolates. Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches. Given the improved resolution, whole-genome assembly of pathogen genomes is likely to become an essential tool for investigation of potential organ transplant transmissions.

Indexed as

Genes, BacterialLiver TransplantationTissue DonorsAgedFemaleHumansMaleMiddle AgedVancomycin-Resistant Enterococci

Identifiers

PMID28301471
PMCPMC5354240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.