Evidence map›Paper›PMID 28301293›Full record

ReviewTranscription2017

Signatures of DNA target selectivity by ETS transcription factors.

Gregory M K Poon, Hye Mi Kim

Open access · bronzeAbstract readReview
In one paragraph

Review in Transcription, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gregory M K Poona Department of Chemistry , Georgia State University , Atlanta , GA , USA.ORCID 0000-0001-5107-9458
Hye Mi Kima Department of Chemistry , Georgia State University , Atlanta , GA , USA.
Georgia State University · US

Funding

Direct activation of hematopoietic transcription factorsR21HL129063 · NHLBI · GEORGIA STATE UNIVERSITY · PI POON, GREGORY MAN KAI · 2015 to 2016
$415k
NHLBI NIH HHS R21 HL129063
6 · The paper itself

Abstract

The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.

Indexed as

AnimalsDNADNA MethylationEpigenesis, GeneticHeterochromatinHumansOsmotic PressureProtein DomainsProto-Oncogene Proteins c-etsDNAHeterochromatinProto-Oncogene Proteins c-etsDNA methylationepigeneticsEts-1ETS transcription factorsmolecular hydrationphylogenyPU.1

Identifiers

PMID28301293
PMCPMC5501379
OpenAlexW2595131753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.