ArticleAutism research : official journal of the International Society for Autism Research2017
Neural correlates of language variability in preschool-aged boys with autism spectrum disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Multimodal predictors of spoken vocabulary development in autism: the role of early childhood brain and behavior.Translational psychiatry · 2026Article
- Article
- Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder.Molecular autism · 2025Article
- Protein-Altering Variants' Analysis in Autism Subgroups Uncovers Early Brain-Expressed Gene Modules Relevant to Autism Pathophysiology.Autism research : official journal of the International Society for Autism Research · 2025Article
- Neuroanatomical basis of language ability in an autism subgroup with moderate language deficits.European child & adolescent psychiatry · 2025Article
- Associations Between Joint Attention, Supported Joint Engagement and Language in TD Children and Children with ASD: Potential Sources of Individual and Group Differences in Language Outcomes.Language learning and development : the official journal of the Society for Language Development · 2025Article
- Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.Quantitative imaging in medicine and surgery · 2024Article
- A global multicohort study to map subcortical brain development and cognition in infancy and early childhood.Nature neuroscience · 2024Article
- Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder.Frontiers in molecular neuroscience · 2023Review
- Brain white matter microstructure abnormalities in children with optimal outcome from autism: a four-year follow-up study.Scientific reports · 2022Article
- Neonatal brain injury influences structural connectivity and childhood functional outcomes.PloS one · 2022Article
- Rethinking Our Concepts and Assumptions About Autism.Frontiers in psychiatry · 2022Article
- Gut Microbiota Implications for Health and Welfare in Farm Animals: A Review.Animals : an open access journal from MDPI · 2021Review
- The neural basis for mental state attribution: A voxel-based lesion mapping study.Human brain mapping · 2021Article
- The Autism Phenome Project: Toward Identifying Clinically Meaningful Subgroups of Autism.Frontiers in neuroscience · 2021Review
- Small Semantic Networks in Individuals with Autism Spectrum Disorder Without Intellectual Impairment: A Verbal Fluency Approach.Journal of autism and developmental disorders · 2020Article
- Reduced White Matter Integrity and Deficits in Neuropsychological Functioning in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Cortical Structure and Cognition in Infants and Toddlers.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1107-1119. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.