Evidence map›Paper›PMID 28301091›Full record

ArticleAutism research : official journal of the International Society for Autism Research2017

Shorter sleep duration is associated with social impairment and comorbidities in ASD.

Olivia J Veatch, James S Sutcliffe, Zachary E Warren, Brendan T Keenan, Melissa H Potter, Beth A Malow

Open access · greenAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Olivia J VeatchDepartment of Neurology, Sleep Disorders Division, Vanderbilt University Medical Center, Nashville, Tennessee.
James S SutcliffeDepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.
Zachary E WarrenDepartment of Pediatric Nashville, Vanderbilt University Medical Center, Nashville, Tennessee.
Brendan T KeenanDepartment of Medicine, Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Melissa H PotterDepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.
Beth A MalowDepartment of Neurology, Sleep Disorders Division, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USUniversity of Pennsylvania · US

Funding

TRAINING PROGRAM/RESPIRATORY NEUROBIOLOGY AND SLEEPT32HL007713 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 1992 to 2022
$11.9M
NHLBI NIH HHS T32 HL007713
6 · The paper itself

Abstract

Sleep disturbance, particularly insomnia, is common in children with autism spectrum disorders (ASD). Furthermore, disturbed sleep affects core symptoms and other related comorbidities. Understanding the causes and consequences of sleep disturbances in children with ASD is an important step toward mitigating these symptoms. To better understand the connection between sleep duration and ASD severity, we analyzed ASD-related symptoms using the Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS), IQ scores, and parent reports of the average amount of time slept per night that were available in the medical histories of 2,714 children with ASD in the Simons Simplex Collection (SSC). The mean (SD) sleep duration was 555 minutes. Sleep duration and severity of core ASD symptoms were negatively correlated, and sleep duration and IQ scores were positively correlated. Regression results indicated that more severe social impairment, primarily a failure to develop peer relationships, is the core symptom most strongly associated with short sleep duration. Furthermore, increased severity for numerous maladaptive behaviors assessed on the Child Behavior Checklist, as well as reports of attention deficit disorder, depressive disorder, and obsessive compulsive disorder were associated with short sleep duration. Severity scores for social/communication impairment and restricted and repetitive behaviors (RRB) were increased, and IQ scores were decreased, for children reported to sleep ≤420 minutes per night (lower 5th percentile) compared to children sleeping ≥660 minutes (upper 95th percentile). Our results indicate that reduced amounts of sleep are related to more severe symptoms in children with ASD. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1221-1238. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Indexed as

Social BehaviorAdolescentAutism Spectrum DisorderChildChild, PreschoolComorbidityFemaleHumansInterpersonal RelationsMaleSeverity of Illness IndexSleepSleep Wake DisordersTime Factorscomorbid conditionsneurologysleep (disorders)social cognitionsubtypes (of ASD)

Identifiers

PMID28301091
PMCPMC7923457
OpenAlexW2595938823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.