Evidence map›Paper›PMID 28300774›Full record

ArticleBiomolecules2017

Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide.

Adeba Mohammad, Adriana Bon Ramos, Bobby W K Lee, Spencer W Cohen, Maryam K Kiani, Dirk Iwata-Reuyl, Boguslaw Stec, Manal A Swairjo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Classification of Protein Disulfide Bonds.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Naturally occurring modified ribonucleosides.Wiley interdisciplinary reviews. RNA · 2020
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Adeba MohammadGraduate College of Biomedical Sciences, Western University of Health Sciences, 309 E. Second Street, Pomona, CA 91766, USA. amohammad@westernu.edu.
Adriana Bon RamosDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, OR 97207, USA. bonramos@pdx.edu.
Bobby W K LeeDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, OR 97207, USA. bowklee@gmail.com.
Spencer W CohenDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, OR 97207, USA. cohens@oregonstate.edu.
Maryam K KianiGraduate College of Biomedical Sciences, Western University of Health Sciences, 309 E. Second Street, Pomona, CA 91766, USA. keemia@gmail.com.
Dirk Iwata-ReuylDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, OR 97207, USA. iwatard@pdx.edu.
Boguslaw StecDepartment of Chemistry and Biochemistry, San Diego State University 5500 Campanile Drive, San Diego, CA 92182, USA. bog.stec.2010@gmail.com.
Manal A SwairjoGraduate College of Biomedical Sciences, Western University of Health Sciences, 309 E. Second Street, Pomona, CA 91766, USA. mswairjo@mail.sdsu.edu.
Portland State University · USSan Diego State University · USWestern University of Health Sciences · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
RNA modification: Structure and MechanismR01GM110588 · NIGMS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI SWAIRJO, MANAL A · 2014 to 2024
$3.9M
NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM110588
6 · The paper itself

Abstract

QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ₀) to 7-aminomethyl-7-deazaguanine (preQ₁) in the biosynthetic pathway to the tRNA modified nucleoside queuosine. The QueF-catalyzed reaction includes formation of a covalent thioimide intermediate with a conserved active site cysteine that is prone to oxidation in vivo. Here, we report the crystal structure of a mutant of

Indexed as

Bacillus subtilisBacterial ProteinsBiocatalysisBiosynthetic PathwaysConserved SequenceCrystallography, X-RayCysteineDisulfidesMutant ProteinsNucleoside QOxidation-ReductionPhylogenyTime FactorsBacterial ProteinsCysteineDisulfidesMutant ProteinsNucleoside QoxidoreductasetRNA modificationtunneling fold

Identifiers

PMID28300774
PMCPMC5372742
OpenAlexW2595630978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.