ArticleChest2017
Sleep Apnea and Hypertension: Are There Sex Differences? The Vitoria Sleep Cohort.
Article in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Cerebral oxidative stress, inflammation and apoptosis induced by intermittent hypoxia: a systematic review and meta-analysis of rodent data.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Socioeconomic status impacts blood pressure response to positive airway pressure treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Role for endothelin-1 in cardiometabolic dysfunction with intermittent hypoxia.Function (Oxford, England) · 2026Review
- Construction of a nomogram prediction model for obstructive sleep apnea combined with hypertension via polysomnography: a single-center retrospective study.European journal of medical research · 2025Article
- Sleep-disordered breathing and metabolic syndrome across gender, age, and sleep subtypes in East Asians.Frontiers in endocrinology · 2025Article
- Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Review
- Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options.Translational stroke research · 2024Review
- Sex-Specific Associations Between Leucocyte Measures and Obstructive Sleep Apnea in Han Chinese.Nature and science of sleep · 2024Article
- On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?The Journal of physiology · 2023Article
- Diagnosis of Obstructive Sleep Apnea Using Feature Selection, Classification Methods, and Data Grouping Based Age, Sex, and Race.Diagnostics (Basel, Switzerland) · 2023Article
- Non-dipping nocturnal blood pressure correlates with obstructive sleep apnoea severity in normotensive subjects and may reverse with therapy.ERJ open research · 2021Article
- Renalase and hypertension-demographic and clinical correlates in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2021Article
- [Study on the structural changes of pharyngeal cavity after bariatric surgery in obese patients with obstructive sleep apnea].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Sex differences in the association between arterial hypertension, blood pressure, and sleep apnea in the general population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Effect of Sleep Disturbances on Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Moderating Effect of BMI on the Relationship Between Sympathetic Activation and Blood Pressure in Males with Obstructive Sleep Apnea.Nature and science of sleep · 2021Article
- The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea.Frontiers in physiology · 2021Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence from longitudinal studies has reported contradictory results regarding the association between OSA and hypertension. In a previous analysis of the Vitoria Sleep Cohort, the relationship between OSA and the risk of developing hypertension was evaluated and no independent association after adjustment for confounding factors was found. In the present study, a post hoc analysis to assess the association between OSA and incident stage 2 hypertension (systolic BP ≥ 160 mm Hg and/or diastolic BP ≥ 100 mm Hg) was made on the basis of sex differences.
methodsA prospective study was performed over 7.5 ± 0.8 years on a middle-aged general population, which included 1,155 normotensive subjects (43.7% men) who completed the follow-up. BP measurements (at baseline and follow-up) and polygraphy at baseline were performed. Logistic regression models were used to determine the association between the respiratory disturbance index (RDI) and stage 2 hypertension and a recursive partitioning method was used to determine the variables related to the incidence of stage 2 hypertension. The RDI was divided into subgroups (0-2.9, 3-6.9, 7-13.9, and ≥ 14), using the first subgroup as reference.
resultsFor men, an RDI ≥ 14 was associated with a significantly increased OR for stage 2 hypertension (OR, 2.54 [95% CI, 1.09-5.95], P = .032). This association was not statistically significant among women (P = .371).
conclusionsThe results suggest an association between moderate and severe OSA, and the incidence of more severe forms of hypertension occurring in men but not in women. However, because this is a community-based study, the women's population characteristics may differ from women usually seen in sleep-disorders clinics.
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Registered trials
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