Evidence map›Paper›PMID 28300394›Full record

ArticleBiochemistry2017

An Asymmetric Conformational Change in LacY.

Irina Smirnova, Vladimir Kasho, Xiaoxu Jiang, H Ronald Kaback

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Function Trumps Form in Two Sugar Symporters,International journal of molecular sciences · 2021
    Review
  3. Mechanisms of ligand binding.Biophysics reviews · 2020
    Review
  4. The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. It takes two to tango: The dance of the permease.The Journal of general physiology · 2019
    Review
  6. Engineered occluded apo-intermediate of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  7. Oversized galactosides as a probe for conformational dynamics in LacY.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Irina SmirnovaDepartment of Physiology, ‡Department of Microbiology, Immunology & Molecular Genetics, and §Molecular Biology Institute, University of California Los Angeles , Los Angeles, California 90095-7327, United States.
Vladimir KashoDepartment of Physiology, ‡Department of Microbiology, Immunology & Molecular Genetics, and §Molecular Biology Institute, University of California Los Angeles , Los Angeles, California 90095-7327, United States.
Xiaoxu JiangDepartment of Physiology, ‡Department of Microbiology, Immunology & Molecular Genetics, and §Molecular Biology Institute, University of California Los Angeles , Los Angeles, California 90095-7327, United States.
H Ronald KabackDepartment of Physiology, ‡Department of Microbiology, Immunology & Molecular Genetics, and §Molecular Biology Institute, University of California Los Angeles , Los Angeles, California 90095-7327, United States.ORCID 0000-0003-0683-5810
University of California, Los Angeles · US

Funding

NEW APPROACHES TO MEMBRANE PROTEIN STRUCTURESR01DK051131 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KABACK, HOWARD RONALD · 1996 to 2014
$5.2M
Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
Dynamics of the Lactose Permease of Escherichia ColiR56DK051131 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KABACK, HOWARD RONALD · 2015 to 2015
$154k
NIDDK NIH HHS R01 DK051131NIDDK NIH HHS R56 DK051131NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

Galactoside/H

Indexed as

ProtonsBinding SitesBiological TransportCysteineDisulfidesEscherichia coliEscherichia coli ProteinsGalactoseGene ExpressionKineticsModels, MolecularMonosaccharide Transport ProteinsOxidation-ReductionProtein BindingProtein DomainsProtein Structure, SecondaryCysteineDisulfidesEscherichia coli ProteinsGalactoseLacY protein, E coliMonosaccharide Transport ProteinsProteolipidsproteoliposomesProtonsSymporters

Identifiers

PMID28300394
PMCPMC5456262
OpenAlexW2595223532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.