Evidence map›Paper›PMID 28300329›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years.

Joseph M Kindler, Norman K Pollock, Emma M Laing, Assaf Oshri, Nathan T Jenkins, Carlos M Isales, Mark W Hamrick, Ke-Hong Ding, Dorothy B Hausman, George P McCabe and 6 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019
    Review
  9. Article
  10. Hypoglycemic Properties of the Aqueous Extract from the Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Joseph M KindlerDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USA.
Norman K PollockDepartment of Pediatrics, Augusta University, Augusta, GA, USA.
Emma M LaingDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USA.
Assaf OshriDepartment of Human Development and Family Science, The University of Georgia, Athens, GA, USA.
Nathan T JenkinsDepartment of Kinesiology, The University of Georgia, Athens, GA, USA.
Carlos M IsalesDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, GA, USA.
Mark W HamrickDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
Ke-Hong DingDepartment of Neuroscience and Regenerative Medicine, Augusta University, Augusta, GA, USA.
Dorothy B HausmanDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USA.
George P McCabeDepartment of Statistics, Purdue University, West Lafayette, IN, USA.
Berdine R MartinDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Kathleen M Hill GallantDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Stuart J WardenDepartment of Physical Therapy, Indiana University, Indianapolis, IN, USA.
Connie M WeaverDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Munro PeacockDepartment of Medicine, Indiana University, Indianapolis, IN, USA.
Richard D LewisDepartment of Foods and Nutrition, The University of Georgia, Athens, GA, USA.
University of Georgia · USPurdue University West Lafayette · USAugusta University · USAugusta University Health · USCenter for Neuroscience and Regenerative Medicine · USIndiana University – Purdue University Indianapolis · USJuliana Kinderziekenhuis · NL

Funding

Supplemental Vitamin D and Functional Outcomes in Early AdolescenceR01HD057126 · NICHD · UNIVERSITY OF GEORGIA · PI LEWIS, RICHARD D · 2009 to 2010
$2.2M
Phosphorus Absorption and Balance in Normal Physiology and Chronic Kidney DiseaseK01DK102864 · NIDDK · UNIVERSITY OF MINNESOTA · PI GALLANT, KATHLEEN M HILL · 2015 to 2019
$692k
NICHD NIH HHS R01 HD057126NIDDK NIH HHS K01 DK102864
6 · The paper itself

Abstract

IGF-I is a pivotal hormone in pediatric musculoskeletal development. Although recent data suggest that the role of IGF-I in total body lean mass and total body bone mass accrual may be compromised in children with insulin resistance, cortical bone geometric outcomes have not been studied in this context. Therefore, we explored the influence of insulin resistance on the relationship between IGF-I and cortical bone in children. A secondary aim was to examine the influence of insulin resistance on the lean mass-dependent relationship between IGF-I and cortical bone. Children were otherwise healthy, early adolescent black and white boys and girls (ages 9 to 13 years) and were classified as having high (n = 147) or normal (n = 168) insulin resistance based on the homeostasis model assessment of insulin resistance (HOMA-IR). Cortical bone at the tibia diaphysis (66% site) and total body fat-free soft tissue mass (FFST) were measured by peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA), respectively. IGF-I, insulin, and glucose were measured in fasting sera and HOMA-IR was calculated. Children with high HOMA-IR had greater unadjusted IGF-I (p < 0.001). HOMA-IR was a negative predictor of cortical bone mineral content, cortical bone area (Ct.Ar), and polar strength strain index (pSSI; all p ≤ 0.01) after adjusting for race, sex, age, maturation, fat mass, and FFST. IGF-I was a positive predictor of most musculoskeletal endpoints (all p < 0.05) after adjusting for race, sex, age, and maturation. However, these relationships were moderated by HOMA-IR (p

Indexed as

Bone DensityInsulin ResistanceAbsorptiometry, PhotonAdolescentBlood GlucoseChildCortical BoneFemaleHumansInsulinInsulin-Like Growth Factor IMaleTibiaTomography, X-Ray ComputedBlood GlucoseInsulinInsulin-Like Growth Factor IBONE QCT/µCTGH/IGF-IpQCTSKELETAL MUSCLE

Identifiers

PMID28300329
PMCPMC5489353
OpenAlexW2596156928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.