ArticleScientific reports2017
Identification of a novel locus associated with skin colour in African-admixed populations.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations.BMC genetics · 2019Pooled it
- Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- The genetic architecture of human skin pigmentation: evolution and adaptation across global populations.Frontiers in genetics · 2026Review
- Integrating whole-genome resequencing data reveals adaptive selection signatures in sheep populations under extreme environments.BMC genomics · 2025Article
- Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery.BMC genomics · 2024Article
- Structural variant landscapes reveal convergent signatures of evolution in sheep and goats.Genome biology · 2024Article
- MC1R and age heteroclassification of face phenotypes in the Rio Grande do Sul population.International journal of legal medicine · 2024Article
- Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks.Genes · 2022Article
- Article
- Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia.Molecular biology and evolution · 2022Article
- Association of pigmentation related-genes polymorphisms and geographic environmental variables in the Chinese population.Hereditas · 2021Article
- Prediction of eye and hair pigmentation phenotypes using the HIrisPlex system in a Brazilian admixed population sample.International journal of legal medicine · 2021Article
- Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency.PLoS genetics · 2021Article
- The evolution of skin pigmentation-associated variation in West Eurasia.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.BMC cancer · 2020Article
- The Evolutionary History of Human Skin Pigmentation.Journal of molecular evolution · 2020Review
- Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure.Clinical, cosmetic and investigational dermatology · 2020Review
- LEI: A Novel Allele Frequency-Based Feature Selection Method for Multi-ancestry Admixed Populations.Scientific reports · 2019Article
- Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb.PLoS genetics · 2019Article
- A curated gene list for expanding the horizons of pigmentation biology.Pigment cell & melanoma research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 12 institutions in 3 countries.
Natalia Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Carlos FloresResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Santos AlonsoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain.
Celeste EngDepartment of Medicine, University of California, San Francisco, CA, United States.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, CA, United States.
Scott HunstmanDepartment of Medicine, University of California, San Francisco, CA, United States.
Donglei HuDepartment of Medicine, University of California, San Francisco, CA, United States.
Marquitta J WhiteDepartment of Medicine, University of California, San Francisco, CA, United States.
Sam S OhDepartment of Medicine, University of California, San Francisco, CA, United States.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, CA, USA.
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Pedro C AvilaAllergy &ENT Associates, Woodlands, TX, USA.
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, USA.
Shannon M ThyneDepartment of Pediatrics, University of California San Francisco, San Francisco General Hospital, San Francisco, CA, USA.
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, CA, USA.
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico.
Saunak SenDivision of Biostatistics, Department of Preventive Medicine, UTHSC, Memphis, TN, USA.
Rajesh KumarChildren's Memorial Hospital and the Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Michael LenoirBay Area Pediatrics, Oakland, CA, USA.
Jose R Rodriguez-SantanaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, CA, United States.
Maria Pino-YanesResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
University of California, San Francisco · USInstituto de Salud Carlos III · ESBaylor College of Medicine · USCentro de Neumologia Pediatrica · PRJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLurie Children's Hospital · USUniversidad de La Laguna · ESUniversity of Tennessee Health Science Center · USUniversity of the Basque Country · ESVA Caribbean Healthcare System · PR
Funding
UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HIATT, ROBERT A · 2012 to 2016
$6.4MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MGenes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8MGenetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1MGene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509kNHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL128439NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS K12 GM081266NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
Abstract
Skin pigmentation is a complex trait that varies largely among populations. Most genome-wide association studies of this trait have been performed in Europeans and Asians. We aimed to uncover genes influencing skin colour in African-admixed individuals. We performed a genome-wide association study of melanin levels in 285 Hispanic/Latino individuals from Puerto Rico, analyzing 14 million genetic variants. A total of 82 variants with p-value ≤1 × 10
Indexed as
Genetic LociAntigens, NeoplasmAntiportersAsian PeopleBlack or African AmericanDNA, IntergenicFemaleGenome-Wide Association StudyGenotypeHispanic or LatinoHumansMaleMembrane Transport ProteinsPhenotypePolymorphism, Single NucleotideProteinsAntigens, NeoplasmAntiportersBEND7 protein, humanDNA, IntergenicMembrane Transport ProteinsProteinsPRPF18 protein, humanRNA Splicing FactorsSLC24A5 protein, humanSLC45A2 protein, human
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.