Evidence map›Paper›PMID 28300197›Full record

ArticleScientific reports2017

Significant decline in anticancer immune capacity during puberty in the Tasmanian devil.

Yuanyuan Cheng, Kim Heasman, Sarah Peck, Emma Peel, Rebecca M Gooley, Anthony T Papenfuss, Carolyn J Hogg, Katherine Belov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yuanyuan ChengSchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
Kim HeasmanSchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
Sarah PeckDepartment of Primary Industries, Parks, Water and Environment, 134 Macquarie Street, Hobart, Tasmania, 7000, Australia.
Emma PeelSchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
Rebecca M GooleySchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
Anthony T PapenfussBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3052, Australia.
Carolyn J HoggSchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
Katherine BelovSchool of Life and Environmental Sciences, The University of Sydney, New South Wales, 2006, Australia.
University of Sydney · AUDepartment of Primary Industries, Parks, Water and Environment · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tasmanian devils (Sarcophilus harrisii) are at risk of extinction in the wild due to Devil Facial Tumour Disease (DFTD), a rare contagious cancer. The prevalence of DFTD differs by age class: higher disease prevalence is seen in adults (2-3 years) versus younger devils (<2 years). Here we propose that immunological changes during puberty may play a role in susceptibility to DFTD. We show that the second year of life is a key developmental period for Tasmanian devils, during which they undergo puberty and pronounced changes in the immune system. Puberty coincides with a significant decrease in lymphocyte abundance resulting in a much higher neutrophil:lymphocyte ratio in adults than subadults. Quantitative PCR analysis of gene expression of transcription factors T-bet and GATA-3 and cytokines interferon gamma (IFN-γ) and interleukin 4 (IL-4) revealed a drastic increase in GATA-3 and IL-4 expression during puberty. These changes led to a significantly lower IFN-γ:IL-4 ratio in 2-year-olds than <1 year olds (on average 1.3-fold difference in males and 4.0-fold in females), which reflects a major shift of the immune system towards Th2 responses. These results all indicate that adult devils are expected to have a lower anticancer immune capacity than subadults, which may explain the observed pattern of disease prevalence of DFTD in the wild.

Indexed as

Sexual MaturationAnimalsBody WeightFemaleGene Expression RegulationInterferon-gammaInterleukin-4Lymphocyte CountLymphocytesMaleMarsupialiaNeoplasmsNeutrophilsProgesteroneTh1 CellsTh2 CellsInterferon-gammaInterleukin-4Progesterone

Identifiers

PMID28300197
PMCPMC5353603
OpenAlexW2596863886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.