ArticleScientific reports2017
Evolution of the chitin synthase gene family correlates with fungal morphogenesis and adaption to ecological niches.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Basidiomycete-specific chitin synthase genes have clade-specific roles in cell wall formation and hyphal development inMicrobiology (Reading, England) · 2026Article
- Cell wall-forming chitin synthases in a chytrid fungus.Npj fungal science · 2026Article
- Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025Review
- Article
- Temperature variability and other climatic attributes linked to genomic features in the lichen-forming fungal genus Umbilicaria.BMC biology · 2025Article
- Article
- Biological efficacy of polyoxin D in crop protection.Journal of pesticide science · 2025Article
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- Transcriptome analysis of different developmental stages ofCurrent research in microbial sciences · 2025Article
- Analysis of the chitin synthase gene family inPeerJ · 2025Article
- Genomic and Expression Analysis of Cassava (Genes · 2024Article
- Pleurotus ostreatus as a model mushroom in genetics, cell biology, and material sciences.Applied microbiology and biotechnology · 2024Review
- ChsA, a Class Ⅱ Chitin Synthase, Contributes to Asexual Conidiation, Mycelial Morphology, Cell Wall Integrity, and the Production of Enzymes and Organic Acids inJournal of fungi (Basel, Switzerland) · 2023Article
- Chitin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2023Review
- The cellular slime mold Fonticula alba forms a dynamic, multicellular collective while feeding on bacteria.Current biology : CB · 2022Article
- The power of the smallest: The inhibitory activity of microbial volatile organic compounds against phytopathogens.Frontiers in microbiology · 2022Review
- Myosin-II proteins are involved in the growth, morphogenesis, and virulence of the human pathogenic fungusFrontiers in cellular and infection microbiology · 2022Article
- Application of Double-Strand RNAs Targeting Chitin Synthase, Glucan Synthase, and Protein Kinase ReducesFrontiers in microbiology · 2021Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fungal kingdom potentially has the most complex chitin synthase (CHS) gene family, but evolution of the fungal CHS gene family and its diversification to fulfill multiple functions remain to be elucidated. Here, we identified the full complement of CHSs from 231 fungal species. Using the largest dataset to date, we characterized the evolution of the fungal CHS gene family using phylogenetic and domain structure analysis. Gene duplication, domain recombination and accretion are major mechanisms underlying the diversification of the fungal CHS gene family, producing at least 7 CHS classes. Contraction of the CHS gene family is morphology-specific, with significant loss in unicellular fungi, whereas family expansion is lineage-specific with obvious expansion in early-diverging fungi. ClassV and ClassVII CHSs with the same domain structure were produced by the recruitment of domains PF00063 and PF08766 and subsequent duplications. Comparative analysis of their functions in multiple fungal species shows that the emergence of ClassV and ClassVII CHSs is important for the morphogenesis of filamentous fungi, development of pathogenicity in pathogenic fungi, and heat stress tolerance in Pezizomycotina fungi. This work reveals the evolution of the fungal CHS gene family, and its correlation with fungal morphogenesis and adaptation to ecological niches.
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