ArticleScientific reports2017
Late assembly of the Vibrio cholerae cell division machinery postpones septation to the last 10% of the cell cycle.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- MatP local enrichment delays segregation independently of tetramer formation and septal anchoring in Vibrio cholerae.Nature communications · 2024Article
- Bacterial growth dynamics in a rhythmic symbiosis.Molecular biology of the cell · 2024Article
- Cell cycle-coordinated maintenance of theEcoSal Plus · 2023Review
- Recovery of Vibrio cholerae polarized cellular organization after exit from a non-proliferating spheroplast state.PloS one · 2023Article
- The chemosensory systems of Vibrio cholerae.Molecular microbiology · 2020Review
- Lytic transglycosylases RlpA and MltC assist in Vibrio cholerae daughter cell separation.Molecular microbiology · 2019Article
- Single molecule super-resolution imaging of bacterial cell pole proteins with high-throughput quantitative analysis pipeline.Scientific reports · 2019Article
- Chemotaxis arrays inJournal of bacteriology · 2018Article
- Enhancing multiplex genome editing by natural transformation (MuGENT) via inactivation of ssDNA exonucleases.Nucleic acids research · 2017Article
- Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli.PLoS genetics · 2017Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial cell division is a highly regulated process, which involves the formation of a complex apparatus, the divisome, by over a dozen proteins. In the few model bacteria in which the division process was detailed, divisome assembly occurs in two distinct steps: a few proteins, including the FtsZ tubulin-like protein, form a membrane associated contractile ring, the Z-ring, at ~30% of the cell cycle. The Z-ring serves as a scaffold for the recruitment of a second series of proteins, including integral membrane and periplasmic cell wall remodelling enzymes, at ~50% of the cell cycle. Actual septation occupies most of the remaining half of the cell cycle. In contrast, we present evidence suggesting that early pre-divisional Z-rings form between 40 and 50% of the cell cycle and mature into fully assembled divisome at about 80% of the cell cycle in Vibrio cholerae. Thus, actual septation is restricted to a very short amount of time. Our results further suggest that late assembly of the divisome probably helps maintain the asymmetric polar organisation of V. cholerae cells by limiting the accumulation of a cell pole marker, HubP, at the nascent cell poles.
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