ArticleNature communications2017
Observation of gold sub-nanocluster nucleation within a crystalline protein cage.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Computationally guided design of bioactive nanostructures for targeted clearance of amyloid-β aggregates in Alzheimer's disease.Nature nanotechnology · 2026Article
- Redesign of the Ferritin Ferroxidase Center for Universal Molecular Binding or Specific Recognition.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Self-assembly of 3D Ternary Crystals Consisting of Biological and Synthetic Nanoparticles.Biomacromolecules · 2026Article
- Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications.Nature communications · 2026Article
- Metalloprotein-Based Nanomedicines: Design Strategies, Functional Mechanisms, and Biomedical Applications.International journal of molecular sciences · 2026Review
- Construction of Efficient Photocatalytic Hydrogen Evolution System using Red Blood Cell Ghosts as Scaffold.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Structural Insight Into a Human H Ferritin@Gold-Monocarbene Adduct: Aurophilicity Revealed in a Biological Context.Angewandte Chemie (International ed. in English) · 2025Article
- Adsorption Behavior of Gold Ions on Nanofiber Webs Containing Protein Polyhedral Crystals.ACS omega · 2025Article
- Molecular Engineering ofMolecules (Basel, Switzerland) · 2023Article
- From Precision Colloidal Hybrid Materials to Advanced Functional Assemblies.Accounts of chemical research · 2022Article
- Fabrication of avidin-stabilized gold nanoclusters with dual emissions and their application in biosensing.Journal of nanobiotechnology · 2022Article
- Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology.ACS bio & med chem Au · 2022Review
- Artificial Protein Cage with Unusual Geometry and Regularly Embedded Gold Nanoparticles.Nano letters · 2022Article
- Design of a gold clustering site in an engineered apo-ferritin cage.Communications chemistry · 2022Article
- Simultaneous Organic and Inorganic Host-Guest Chemistry within Pillararene-Protein Cage Frameworks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Protein Assembly by Design.Chemical reviews · 2021Review
- Enhanced Cellular Uptake of H-Chain Human Ferritin Containing Gold Nanoparticles.Pharmaceutics · 2021Article
- Engineered Repeat Protein Hybrids: The New Horizon for Biologic Medicines and Diagnostic Tools.Accounts of chemical research · 2021Article
- Modern cluster design based on experiment and theory.Nature reviews. Chemistry · 2021Review
- Engineering multifunctional metal/protein hybrid nanomaterials as tools for therapeutic intervention and high-sensitivity detection.Chemical science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein scaffolds provide unique metal coordination environments that promote biomineralization processes. It is expected that protein scaffolds can be developed to prepare inorganic nanomaterials with important biomedical and material applications. Despite many promising applications, it remains challenging to elucidate the detailed mechanisms of formation of metal nanoparticles in protein environments. In the present work, we describe a crystalline protein cage constructed by crosslinking treatment of a single crystal of apo-ferritin for structural characterization of the formation of sub-nanocluster with reduction reaction. The crystal structure analysis shows the gradual movement of the Au ions towards the centre of the three-fold symmetric channels of the protein cage to form a sub-nanocluster with accompanying significant conformational changes of the amino-acid residues bound to Au ions during the process. These results contribute to our understanding of metal core formation as well as interactions of the metal core with the protein environment.
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