Evidence map›Paper›PMID 28300059›Full record

ArticleGenes and immunity2017

Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections.

C Vergara, C Thio, R Latanich, A L Cox, G D Kirk, S H Mehta, M Busch, E L Murphy, M C Villacres, M G Peters and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 1 country.

C VergaraSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
C ThioSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
R LatanichSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
A L CoxSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
G D KirkBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
S H MehtaBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
M BuschUniversity of California, San Francisco, CA, USA.
E L MurphyUniversity of California, San Francisco, CA, USA.
M C VillacresKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
M G PetersBlood Systems Research Institute, San Francisco, CA, USA.
A L FrenchCORE Center/Stroger Hospital of Cook County, Chicago, IL, USA.
E GolubBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
J EronUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
C D LahiriSchool of Medicine, Emory University, Atlanta, GA, USA.
S ShresthaThe University of Alabama at Birmingham, AL, USA.
D GustafsonState University of New York-Downstate Medical Center, New York, NY, USA.
M YoungGeorgetown University Medical Center, Washington, DC, USA.
K AnastosAlbert Einstein College of Medicine and Montefiore Medical Center, New York, NY, USA.
B AouizeratBluestone Center for Clinical Research, New York University, New York, NY, USA.
A Y KimMassachusetts General Hospital, Boston, MA, USA.
G LauerMassachusetts General Hospital, Boston, MA, USA.
D L ThomasSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
P DuggalBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USBlood Systems Research Institute · USHarvard University · USAlbert Einstein College of Medicine · USCenter for Clinical Research (United States) · USEmory University · USGeorgetown University Medical Center · USJohn H. Stroger, Jr. Hospital of Cook County · USState University of New York · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
NCATS NIH HHS KL2 TR000143NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NHLBI NIH HHS U01 HL146203NIAID NIH HHS K23 AI124913NIAID NIH HHS K24 AI118591NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI108403NIAID NIH HHS R38 AI140299NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIAID NIH HHS U01 AI131314NIAID NIH HHS U19 AI066345NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI088791NIA NIH HHS U54 AG062334NICHD NIH HHS U01 HD032632NIDA NIH HHS R01 DA012568NIDA NIH HHS R01 DA013324NIDA NIH HHS R01 DA033541NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are associated with elevated IL-18, suggesting inflammasome activation. However, there is marked person-to-person variation in the inflammasome response to HCV and HIV. We hypothesized that host genetics may explain this variation. To test this, we analyzed the associations of plasma IL-18 levels and polymorphisms in 10 genes in the inflammasome cascade. About 1538 participants with active HIV and/or HCV infection in three ancestry groups are included. Samples were genotyped using the Illumina Omni 1-quad and Omni 2.5 arrays. Linear regression analyses were performed to test the association of variants with log IL-18 including HCV and HIV infection status, and HIV RNA in each ancestry group and then meta-analyzed. Eleven highly correlated single-nucleotide polymorphisms (r

Indexed as

AdultCoinfectionDioxygenasesFemaleHepatitis C, ChronicHIV-1HIV InfectionsHumansInflammasomesInterleukin-18MalePolymorphism, Single NucleotideBCO2 protein, humanDioxygenasesInflammasomesInterleukin-18

Identifiers

PMID28300059
PMCPMC5408324
OpenAlexW2596476842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.