SynthesisInfection control and hospital epidemiology2017
Clostridium Difficile Infection in Acute Care Hospitals: Systematic Review and Best Practices for Prevention.
Synthesis in Infection control and hospital epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Evidence Map and Systematic Review of Disinfection Efficacy on Environmental Surfaces in Healthcare Facilities.International journal of environmental research and public health · 2021Pooled it
- Environmental Cleaning and Decontamination to Prevent Clostridioides difficile Infection in Health Care Settings: A Systematic Review.Journal of patient safety · 2020Pooled it
- Pooled it
- Implementation strategies for hospital-based probiotic administration in a stepped-wedge cluster randomized trial design for preventing hospital-acquired Clostridioides difficile infection.BMC health services research · 2023Trial
- Development of a checklist to support management of older patients withBMJ open quality · 2026Article
- Trends and Disparities inGastroenterology research and practice · 2026Article
- Isolation ofAnimals : an open access journal from MDPI · 2025Article
- Comparison ofJournal of clinical medicine · 2025Article
- Clinical value of PDCA circulation nursing in reducing nosocomial infection.Frontiers in medicine · 2025Article
- Lateral effects of infection prevention measures during COVID-19 pandemic on hospital-acquiredJournal of infection prevention · 2024Article
- Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan.Scientific reports · 2024Article
- Article
- Review
- Sustained free chlorine-releasing polydimethylsiloxane/Ca(ClO)RSC advances · 2024Article
- Understanding clinical implementation coordinators' experiences in deploying evidence-based interventions.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2024Article
- A critical assessment of microbial-based antimicrobial sanitizing of inanimate surfaces in healthcare settings.Frontiers in microbiology · 2024Review
- Investigating the Effects of NosocomialHCA healthcare journal of medicine · 2024Article
- Treated, hospital-onsetInfection control and hospital epidemiology · 2024Article
- Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Identification of outcomes reported for hospital antimicrobial stewardship interventions using a systematic review of reviews.JAC-antimicrobial resistance · 2023Review
Corrections and comments
- Commented on by
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
OBJECTIVE Prevention of Clostridium difficile infection (CDI) in acute-care hospitals is a priority for hospitals and clinicians. We performed a qualitative systematic review to update the evidence on interventions to prevent CDI published since 2009. DESIGN We searched Ovid, MEDLINE, EMBASE, The Cochrane Library, CINAHL, the ISI Web of Knowledge, and grey literature databases from January 1, 2009 to August 1, 2015. SETTING We included studies performed in acute-care hospitals. PATIENTS OR PARTICIPANTS We included studies conducted on hospitalized patients that investigated the impact of specific interventions on CDI rates. INTERVENTIONS We used the QI-Minimum Quality Criteria Set (QI-MQCS) to assess the quality of included studies. Interventions were grouped thematically: environmental disinfection, antimicrobial stewardship, hand hygiene, chlorhexidine bathing, probiotics, bundled approaches, and others. A meta-analysis was performed when possible. RESULTS Of 3,236 articles screened, 261 met the criteria for full-text review and 46 studies were ultimately included. The average quality rating was 82% according to the QI-MQCS. The most effective interventions, resulting in a 45% to 85% reduction in CDI, included daily to twice daily disinfection of high-touch surfaces (including bed rails) and terminal cleaning of patient rooms with chlorine-based products. Bundled interventions and antimicrobial stewardship showed promise for reducing CDI rates. Chlorhexidine bathing and intensified hand-hygiene practices were not effective for reducing CDI rates. CONCLUSIONS Daily and terminal cleaning of patient rooms using chlorine-based products were most effective in reducing CDI rates in hospitals. Further studies are needed to identify the components of bundled interventions that reduce CDI rates. Infect Control Hosp Epidemiol 2017;38:476-482.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.