ArticleGeroScience2017
The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age.
Article in GeroScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prehabilitation in Frail Surgical Patients: A Systematic Review.World journal of surgery · 2020Pooled it
- A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Pooled it
- The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis.Clinical epigenetics · 2019Pooled it
- Temporal sequencing of sensory impairments and frailty reveals vulnerability-dependent dementia risk.Research square · 2026Article
- From whole-body to organ-specific biological age clocks.Nature aging · 2026Review
- Comprehensive cross-sectional and longitudinal comparison of sixteen markers of biological aging from the Berlin Aging Study II.Communications medicine · 2026Article
- Integrating supervised and unsupervised machine learning for behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred mice.bioRxiv : the preprint server for biology · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025Review
- Frailty Index Predicts Future All-cause Mortality and Quality of Life: A 2-Year Follow-up Study Among Korean Older Adults From a Population-based Cohort Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Unveiling the genetic biomarkers for ageing: evidence from a large sample genome-wide association study and in vivo validation.Journal of global health · 2025Article
- Roadmap for alleviating the manifestations of ageing in the cardiovascular system.Nature reviews. Cardiology · 2025Review
- Machine vision-based frailty assessment for genetically diverse mice.GeroScience · 2025Article
- Epigenetic Biomarkers of Cardiovascular Risk in Frail Patients-A Scope Review.Current issues in molecular biology · 2025Review
- A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging.Journal of cachexia, sarcopenia and muscle · 2025Article
- Biological age and clinical frailty scale measured at intensive care unit admission as predictors of hospital mortality among the critically ill in Western Australia: a retrospective cohort study.Acute and critical care · 2025Article
- The Mouse Social Frailty Index (mSFI): A Standardized Protocol.Bio-protocol · 2025Article
- Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction.GeroScience · 2025Article
- Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing.Age and ageing · 2025Article
- Analysis of the Correlation between Frailty Index, Clinical Characteristics, Use of Anti-Epileptic Drug, and Prognosis in Elderly Patients with Epilepsy.Actas espanolas de psiquiatria · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The measurement of biological age as opposed to chronological age is important to allow the study of factors that are responsible for the heterogeneity in the decline in health and function ability among individuals during aging. Various measures of biological aging have been proposed. Frailty indices based on health deficits in diverse body systems have been well studied, and we have documented the use of a frailty index (FI
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.