Evidence map›Paper›PMID 28299636›Full record

ArticleGeroScience2017

Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.

Silvan R Urfer, Tammi L Kaeberlein, Susan Mailheau, Philip J Bergman, Kate E Creevy, Daniel E L Promislow, Matt Kaeberlein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Translational geroscience: A new paradigm for 21Translational medicine of aging · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Silvan R UrferDepartment of Pathology, University of Washington, Seattle, WA, USA.
Tammi L KaeberleinDepartment of Pathology, University of Washington, Seattle, WA, USA.
Susan MailheauDog Aging Project, Seattle, WA, USA.
Philip J BergmanVCA Clinical Studies, Los Angeles, CA, USA.
Kate E CreevyDog Aging Project, Seattle, WA, USA.
Daniel E L PromislowDepartment of Pathology, University of Washington, Seattle, WA, USA.
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA, USA. kaeber@uw.edu.ORCID 0000-0002-1311-3421
University of Washington · USClinical Research Associates · USTexas A&M University · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Su-In Lee · 1995 to 2026
$27.1M
The Domestic Dog as a Model System for Aging ResearchR24AG044284 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2013 to 2015
$419k
NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS R24 AG044284
6 · The paper itself

Abstract

Heart disease is the leading cause of death in the USA, accounting for about one in every four deaths. Age is the greatest risk factor for heart disease in both people and dogs; however, heart disease is generally not considered as a major cause of morbidity or mortality in dogs. As part of the preliminary selection process for a veterinary clinical trial, 40 companion dogs with no history of cardiac pathology that were at least 6 years old and weighed at least 18 kg underwent a cardiac screening using Doppler echocardiography. Eleven dogs from this cohort were diagnosed with valvular regurgitation by echocardiography, and seven of these cases were of sufficient severity to warrant exclusion from the clinical trial. In only one case was a heart murmur detected by auscultation. Serum alkaline phosphatase levels were significantly higher in the dogs with moderate to severe valvular regurgitation compared to the rest of the cohort. These observations suggest that asymptomatic degenerative valvular disease detectable by echocardiography, but not by a standard veterinary exam including auscultation, may be present in a significant fraction of middle-aged companion dogs, indicating a previously underappreciated similarity between human and canine aging. Further, these data suggest that companion dogs may be a particularly useful animal model for understanding mechanisms of age-related degenerative valve disease and for developing and testing interventions to ameliorate cardiac disease. Future studies should address whether dogs with asymptomatic valve disease are at higher risk for subsequent morbidity or early death.

Indexed as

Asymptomatic DiseasesAgingAnimalsDog DiseasesDogsEchocardiography, DopplerFemaleHeart Valve DiseasesHumansMiddle AgedMitral Valve InsufficiencyRandom AllocationReference ValuesRisk AssessmentSurvival RateCardiac agingDegenerative valve diseaseDogsEchocardiogramRegurgitation

Identifiers

PMID28299636
PMCPMC5352585
OpenAlexW2572496189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.