Evidence map›Paper›PMID 28299632›Full record

ArticleInternational journal of hematology2017

Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19

Jeffrey D McBride, Xiaochen Liu, William L Berry, Ralf Janknecht, Rui Cheng, Kelu Zhou, Evangelos V Badiavas, Jian-Xing Ma

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Wnt Signaling in vascular eye diseases.Progress in retinal and eye research · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jeffrey D McBrideDepartment of Cell Biology, University of Oklahoma Health Sciences Center, BSEB 328B, 941 Stanton L. Young Blvd, Oklahoma City, OK, 73104-5020, USA.
Xiaochen LiuDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
William L BerryDepartment of Cell Biology, University of Oklahoma Health Sciences Center, BSEB 328B, 941 Stanton L. Young Blvd, Oklahoma City, OK, 73104-5020, USA.
Ralf JanknechtDepartment of Cell Biology, University of Oklahoma Health Sciences Center, BSEB 328B, 941 Stanton L. Young Blvd, Oklahoma City, OK, 73104-5020, USA.
Rui ChengDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kelu ZhouDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Evangelos V BadiavasDepartment of Dermatology, Miller School of Medicine, University of Miami, Miami, USA.
Jian-Xing MaDepartment of Cell Biology, University of Oklahoma Health Sciences Center, BSEB 328B, 941 Stanton L. Young Blvd, Oklahoma City, OK, 73104-5020, USA. jian-xing-ma@ouhsc.edu.
University of Oklahoma Health Sciences Center · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Members of the family of serine proteinase inhibitors, such as kallistatin, have been shown to inhibit canonical Wnt-TCF/LEF-β-catenin signaling via their interactions with the Wnt co-receptor LRP6. Yet the effects of transgenic overexpression of anti-Wnt serpins on hematopoiesis and lymphopoiesis are not well known. We studied the effects of human kallistatin (SERPINA4) on Wnt reporter activity in various cell types throughout the hematopoietic system and associated impacts on circulating white blood cell profiles. Transgenic overexpression of kallistatin suppressed Wnt-TCF/LEF-β-catenin signaling in bone marrow, as demonstrated using a Wnt reporter mouse. Further, kallistatin overexpression and treatment were associated with reduced Wnt-TCF/LEF-β-catenin activity in CD34

Indexed as

AnimalsAntigens, CDAntigens, CD19B-LymphocytesChickensHumansLymphopoiesisMiceMice, TransgenicSerpinsT-LymphocytesWnt ProteinsWnt Signaling PathwayAntigens, CDAntigens, CD19CD19 antigen, mousekallistatinSerpinsWnt ProteinsBone marrowHematopoiesisLymphocyteSerpinStem cellWnt

Identifiers

PMID28299632
OpenAlexW2599644787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.