ArticleJournal of assisted reproduction and genetics2017
Elective single blastocyst transfer in advanced maternal age.
Article in Journal of assisted reproduction and genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Comparisons of benefits and risks of single embryo transfer versus double embryo transfer: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2022Pooled it
- Extended embryo culture is effective for patients of an advanced maternal age.Scientific reports · 2021Trial
- A predictive model for high-quality blastocyst formation using Day 3 morphological scores in women of advanced maternal age.BMC pregnancy and childbirth · 2026Article
- What is the optimal number of embryos to transfer for POSEIDON group 1 and group 2? A retrospective study.Journal of ovarian research · 2024Article
- Single versus double blastocyst transfer in first and second frozen-thawed embryo transfer cycle in advance-aged women: a two-center retrospective cohort study.BMC women's health · 2024Article
- The effect of intrauterine insemination preceding frozen-thawed elective single embryo transfer in couples with unexplained subfertility.Archives of medical science : AMS · 2024Article
- Assisted Reproductive Technology without Embryo Discarding or Freezing in Women ≥40 Years: A 5-Year Retrospective Study at a Single Center in Italy.Journal of clinical medicine · 2023Article
- Comparison of frozen-thaw blastocyst transfer strategies in women aged 35-40 years: a retrospective study.Frontiers in endocrinology · 2023Article
- A proof of concept for a deep learning system that can aid embryologists in predicting blastocyst survival after thaw.Scientific reports · 2022Article
- Effect of double embryo transfer derived from autologous frozen oocytes on multiple pregnancy rates and presentation of success rates stratified by age at retrievalJournal of the Turkish German Gynecological Association · 2021Article
- Single-embryo transfer: a key strategy to reduce the risk for multiple pregnancy in assisted human reproduction.Advances in laboratory medicine · 2021Review
- Pregnancy Outcomes of Single/Double Blastocysts and Cleavage Embryo Transfers: a Retrospective Cohort Study of 24,422 Frozen-Thawed Cycles.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Live birth rate and neonatal outcomes of different quantities and qualities of frozen transferred blastocyst in patients requiring whole embryo freezing stratified by age.BMC pregnancy and childbirth · 2020Article
- Does the transfer of a poor quality embryo with a good quality embryo benefit poor prognosis patients?Reproductive biology and endocrinology : RB&E · 2020Article
- A stepwise approach to move from a cleavage-stage to a blastocyst-stage transfer policy for all patients in the IVF clinic.Human reproduction open · 2020Article
- The Feasibility of All-Blastocyst-Culture and Single Blastocyst Transfer Strategy in Elderly Women: A Retrospective Analysis.BioMed research international · 2020Article
- Article
- Effect of embryo and blastocyst transfer on the birthweight of live-born singletons from FET cycles.Journal of assisted reproduction and genetics · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate reproductive outcomes following elective single blastocyst transfer (eSBT) compared with those of double blastocyst transfer (DBT) in advanced maternal age.
methodsThis was a retrospective cohort study performed at an academic fertility center. All women aged 40 and over for whom in vitro fertilization (IVF) cycles were performed and in whom embryo culture was extended to the blastocyst stage were reviewed for possible inclusion. Exclusion criteria included the following: women with >3 previous IVF cycles, the use of donor or frozen oocytes, preimplantation genetic diagnosis/preimplantation genetic screening cycles, and cycles in which embryos did not reach the blastocyst stage on day 5. The study included 310 women; 148 were included in the eSBT group and 162 were included in the DBT group. Live birth rate (LBR) was the main outcome. Outcomes were analyzed using logistic regression, controlling for confounders. These confounders were embryo expansion, embryo quality, and the number of previous IVF cycles.
resultsThe mean age of the whole group was 41 ± 0.91 years, and the LBR was 21.6%. The eSBT group and the DBT group achieved similar clinical pregnancy rates (33 vs. 33%) (OR 1.04; 95%CI, 0.62-1.75) and LBRs (20 vs. 22.8%) (OR 1.43; 95% CI, 0.78-2.64). The multiple birth rate was lower in the eSBT group (0 vs. 16%, p = 0.02). The subgroup of women who had elective DBT (eDBT) achieved a higher LBR (20 vs. 30.6%) (OR 2.32; 95% CI, 1.16-4.68) and a higher multiple birth rate (0 vs. 22%, p = 0.001). Cycles with early blastocyst transfers were associated with lower LBRs compared with cycles with fully expanded blastocyst transfers (11 vs. 24%, p = 0.02).
conclusionThe results of this study indicate that eSBT is associated with similar LBRs compared to the entire DBT cohort; however, when supernumerary blastocysts are available for cryopreservation, eDBT is associated with both higher LBRs and a higher number of multiple births. Studies assessing the cumulative LBR in advanced maternal age after single blastocyst transfer and subsequent frozen-thawed blastocyst transfers are needed.
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Registered trials
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