Evidence map›Paper›PMID 28299490›Full record

ArticleLasers in medical science2017

Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models.

Laurenz Schmitt, P M Amann, Y Marquardt, R Heise, K Czaja, P A Gerber, T Steiner, F Hölzle, Jens Malte Baron

Abstract read
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Article in Lasers in medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Effect of Different Wavelengths of Laser Irradiation on the Skin Cells.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Review
  12. Use of Er:YAG laser in the treatment of vulvar lichen sclerosus.International journal of women's dermatology · 2019
    Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laurenz SchmittDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. lschmitt@ukaachen.de.ORCID http://orcid.org/0000-0003-0989-5587
P M AmannDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Y MarquardtDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
R HeiseDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
K CzajaDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
P A GerberDepartment of Dermatology and Allergology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
T SteinerDepartment of Oral and Maxillofacial Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
F HölzleDepartment of Oral and Maxillofacial Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Jens Malte BaronDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. JensMalte.Baron@post.rwth-aachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular changes in gene expression following ablative laser treatment of skin lesions, such as atrophic scars and UV-damaged skin, are not completely understood. A standardized in vitro model of human skin, to study the effects of laser treatment on human skin, has been recently developed. Therefore, the aim of the investigation was to examine morphological and molecular changes caused by fractional ablative erbium:YAG laser treatment on an in vitro full-thickness 3D standardized organotypic model of human skin. A fractional ablative erbium:YAG laser was used to irradiate organotypic human 3D models. Laser treatments were performed at four different settings using a variety of stacked pulses with similar cumulative total energy fluence (60 J/cm

Indexed as

Models, BiologicalBiomarkersCell DifferentiationChemokinesChildDermisFilaggrin ProteinsGene Expression RegulationHumansLasers, Solid-StateLaser TherapyMaleOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionReference StandardsRNA, MessengerBiomarkersChemokinesFilaggrin ProteinsFLG2 protein, humanFLG protein, humanRNA, MessengerFractional erbium:YAG laserGene expressionMolecular effectsOrganotypic skin equivalentsResurfacingWound healing

Identifiers

PMID28299490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.