Evidence map›Paper›PMID 28299430›Full record

ArticleMedical microbiology and immunology2017

Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana.

Christian Lundtoft, Anthony Afum-Adjei Awuah, Norman Nausch, Anthony Enimil, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Medical microbiology and immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Two-HitFrontiers in immunology · 2019
    Trial
  3. Immune Sensitization toPathogens (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Christian LundtoftPediatric Infectious Diseases Group, Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany.
Anthony Afum-Adjei AwuahKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Norman NauschPediatric Infectious Diseases Group, Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany.
Anthony EnimilKomfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
Ertan MayatepekPediatric Infectious Diseases Group, Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany.
Ellis Owusu-DaboKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Marc JacobsenPediatric Infectious Diseases Group, Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany. marc.jacobsen@med.uni-duesseldorf.de.
Düsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DEKwame Nkrumah University of Science and Technology · GHKomfo Anokye Teaching Hospital · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON

Indexed as

AdolescentChildChild, PreschoolCoinfectionCytokinesFemaleGhanaHIV InfectionsHumansInfantInterferon-gamma Release TestsMaleMycobacterium tuberculosisSensitivity and SpecificityTuberculosisCytokinesCytometric bead assayHIV co-infectionIL-21IL-6QuantiFERON (QFT)Tuberculosis

Identifiers

PMID28299430
OpenAlexW2607486105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.