ArticleEuropean journal of clinical pharmacology2017
Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort study.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Drug-Drug Interaction Signals for Major Bleeding in Nursing Home Residents: High-Throughput Screening of Clopidogrel and Oral Anticoagulants.Pharmacoepidemiology and drug safety · 2026Article
- Managing High-Risk Drug Interactions With Nirmatrelvir/Ritonavir: Experience From a Dedicated Pharmacology Advice Service.Clinical and translational science · 2026Article
- Prevalence and clinical significance of potential drug-drug interactions of antimicrobials in Intensive Care Unit patients: a retrospective study.BMC pharmacology & toxicology · 2025Article
- Drug interactions in a sample of inpatients diagnosed with cannabis use disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- A comparison of five different drug-drug interaction checkers for selective serotonin reuptake inhibitors.Frontiers in pharmacology · 2025Article
- Clinical Significance and Patterns of Potential Drug-Drug Interactions in Cardiovascular Patients: Focus on Low-Dose Aspirin and Angiotensin-Converting Enzyme Inhibitors.Journal of clinical medicine · 2024Article
- Agreement of Different Drug-Drug Interaction Checkers for Proton Pump Inhibitors.JAMA network open · 2024Article
- Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department.Frontiers in pharmacology · 2024Article
- Risk Factors for Potential Drug-Drug Interactions in Outpatients with Dyslipidemia.Iranian journal of public health · 2023Article
- Potential Drug-Drug Interactions among Patients with Schizophrenia Spectrum Disorders: Prevalence, Association with Risk Factors, and Replicate Analysis in 2021.Medicina (Kaunas, Lithuania) · 2023Observational
- Potential Drug Interactions in Adults Living in Manaus: A Real-World Comparison of Two Databases, 2019.Turkish journal of pharmaceutical sciences · 2022Article
- Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients.BMC geriatrics · 2021Article
- Current Knowledge about Providing Drug-Drug Interaction Services for Patients-A Scoping Review.Pharmacy (Basel, Switzerland) · 2021Article
- Potential drug-drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria.Malaria journal · 2020Article
- Potential drug interactions with antibacterials in long-term care facilities analyzed by two interaction checkers.International journal of clinical pharmacy · 2019Article
- Safety and Tolerability of Pharmacotherapies for Parkinson's Disease in Geriatric Patients.Drugs & aging · 2019Review
- PharmActa: Empowering Patients to Avoid Clinical Significant Drug⁻Herb Interactions.Medicines (Basel, Switzerland) · 2019Article
- Comparative review of drug-drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer.OncoTargets and therapy · 2019Review
- Evaluation of Clinical Relevance of Drug-Drug Interaction Alerts Prior to Implementation.Applied clinical informatics · 2018Article
- Potential Drug Interactions in Hospitalized Hematologic Cancer Patients: New Update with New Chemotherapy Regimens.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDrug-drug interaction (DDI) screening systems report potential DDIs. This study aimed to find the prevalence of probable DDI-related adverse drug reactions (ADRs) and compare the clinical usefulness of different DDI screening systems to prevent or warn against these ADRs.
methodsA prospective cohort study was conducted in patients urgently admitted to medical departments. Potential DDIs were checked using Complete Drug Interaction®, Lexicomp® Online™, and Drug Interaction Checker®. The study team identified the patients with probable clinically relevant DDI-related ADRs on admission, the causality of which was assessed using the Drug Interaction Probability Scale (DIPS). Sensitivity, specificity, and positive and negative predictive values of screening systems to prevent or warn against probable DDI-related ADRs were evaluated.
resultsOverall, 50 probable clinically relevant DDI-related ADRs were found in 37 out of 795 included patients taking at least two drugs, most common of them were bleeding, hyperkalemia, digitalis toxicity, and hypotension. Complete Drug Interaction showed the best sensitivity (0.76) for actual DDI-related ADRs, followed by Lexicomp Online (0.50), and Drug Interaction Checker (0.40). Complete Drug Interaction and Drug Interaction Checker had positive predictive values of 0.07; Lexicomp Online had 0.04. We found no difference in specificity and negative predictive values among these systems.
conclusionDDI screening systems differ significantly in their ability to detect probable clinically relevant DDI-related ADRs in terms of sensitivity and positive predictive value.
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