Evidence map›Paper›PMID 28299369›Full record

ArticleThe Lancet. Public health2016

Socioeconomic status and treatment outcomes for individuals with HIV on antiretroviral treatment in the UK: cross-sectional and longitudinal analyses.

Lisa S Burch, Colette J Smith, Jane Anderson, Lorraine Sherr, Alison J Rodger, Rebecca O'Connell, Anna-Maria Geretti, Richard Gilson, Martin Fisher, Jonathan Elford and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05953844 (Adherence to Antiretroviral Therapy in HIV Infected Individuals in Assiut Governorate, Egypt), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05953844 unknown statusnot on this mapstarted 2023, after this paper: background citation

Adherence to Antiretroviral Therapy in HIV Infected Individuals in Assiut Governorate, Egypt

TypeobservationalSponsorAssiut UniversityRan2023 to 2025Enrolled278ConditionsHIV Infections
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. A Single Centre Retrospective Cohort Analysis of HIV Associated Lymphoma from Northern India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lisa S BurchResearch Department of Infection and Population Health, University College London, London, UK.
Colette J SmithResearch Department of Infection and Population Health, University College London, London, UK.
Jane AndersonCentre for the Study of Sexual Health and HIV, Homerton University Hospital NHS Foundation Trust, London, UK.
Lorraine SherrResearch Department of Infection and Population Health, University College London, London, UK.
Alison J RodgerResearch Department of Infection and Population Health, University College London, London, UK.
Rebecca O'ConnellBarts Health NHS Trust, London, UK.
Anna-Maria GerettiInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Richard GilsonResearch Department of Infection and Population Health, University College London, London, UK.
Martin FisherRoyal Sussex County Hospital, Brighton, UK.
Jonathan ElfordSchool of Health Sciences, City, University of London, London, UK.
Martin JonesEast Sussex Healthcare NHS Trust, Eastbourne, UK.
Simon CollinsHIV i-Base, London, UK.
Yusef AzadNational AIDS Trust, London, UK.
Andrew N PhillipsResearch Department of Infection and Population Health, University College London, London, UK.
Andrew SpeakmanResearch Department of Infection and Population Health, University College London, London, UK.
Margaret A JohnsonRoyal Free London NHS Foundation Trust, London, UK.
Fiona C LampeResearch Department of Infection and Population Health, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed to investigate the association of socioeconomic factors with antiretroviral therapy (ART) non-adherence, virological non-suppression, and virological rebound, in HIV-positive people on ART in the UK.

methodsWe used data from the Antiretrovirals, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study, which recruited participants aged 18 years or older with HIV from eight HIV outpatient clinics in the UK between Feb 1, 2011, and Dec 31, 2012. Participants self-completed a confidential questionnaire on sociodemographic, health, and lifestyle issues. In participants on ART, we assessed associations of financial hardship, employment, housing, and education with: self-reported ART non-adherence at the time of the questionnaire; virological non-suppression (viral load >50 copies per mL) at the time of questionnaire in those who started ART at least 6 months ago (cross-sectional analysis); and subsequent virological rebound (viral load >200 copies per mL) in those with initial viral load of 50 copies per mL or lower (longitudinal analysis).

findingsOf the 3258 people who completed the questionnaire, 2771 (85%) reported being on ART at the time of the questionnaire, and 2704 with complete data were included. 873 (32%) of 2704 participants reported non-adherence to ART and 219 (9%) of 2405 had virological non-suppression in cross-sectional analysis. Each of the four measures of lower socioeconomic status was strongly associated with non-adherence to ART, and with virological non-suppression (prevalence ratios [PR] adjusted for gender/sexual orientation, age, and ethnic origin: greatest financial hardship

interpretationSocioeconomic disadvantage was strongly associated with poorer HIV treatment outcomes in this setting with universal health care. Adherence interventions and increased social support for those most at risk should be considered.

fundingNational Institute for Health Research.

Identifiers

PMID28299369
PMCPMC5341147

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.